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Cognitive impairment and dementia – an update
Cognitive impairment and dementia afflict a large number of people worldwide, being a major source of disability and loss of income. The amount of research on this subject is extensive, covering from basic to translational and clinical aspects. Therefore, it is hard to keep up with the amount of publications and novelties in this field, especially for the busy clinician. On the other hand, basic scientists often find it difficult to explore the vast clinical literature on this matter, as well as understand the clinical features of these disorders and to define the current research needs and directions. The main aim of this Frontiers Research Topic is to provide a solid and valuable platform of scientific synthesis regarding the current knowledge and literature on this theme, including clinical features, current and emergent diagnostic strategies, management (both present and future), and other important issues pertaining to cognitive impairment and dementia.
Neurodegenerative Diseases
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Hyperkinetic Movement Disorders, with Desktop Edition
Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evi...
Aging and Mental Health
People are progressively ageing all over the world, and it is estimated that the number of persons aged 60 or over will more than triple by 2100. This emerging population will experience an inevitable rise in dementia, mental health problems and chronic diseases. According to GBD (2010), neuropsychiatric disorders among older adults account for 6.6% of the total disability (DALYs) for this age group, with 15% suffering from a mental disorder. Multiple social, psychological and biological factors are determinant of mental health, as well as life stressors. Among these, the lack of independence, limited mobility, chronic diseases, pain, frailty or other mental and physical problems require lon...
Predictive Intelligence Using Big Data and the Internet of Things
With the recent growth of big data and the internet of things (IoT), individuals can now upload, retrieve, store, and collect massive amounts of information to help drive decisions and optimize processes. Due to this, a new age of predictive computing is taking place, and data can now be harnessed to predict unknown occurrences or probabilities based on data collected in real time. Predictive Intelligence Using Big Data and the Internet of Things highlights state-of-the-art research on predictive intelligence using big data, the IoT, and related areas to ensure quality assurance and compatible IoT systems. Featuring coverage on predictive application scenarios to discuss these breakthroughs in real-world settings and various methods, frameworks, algorithms, and security concerns for predictive intelligence, this book is ideally designed for academicians, researchers, advanced-level students, and technology developers.
Manitoba Law Journal Volume 44 Issue 4 Robson Crim - Defences and the Criminal Law (2021)
The Manitoba Law Journal (MLJ) is a peer-reviewed journal founded in 1961. The MLJ's current mission is to provide lively, independent and high caliber commentary on legal events in Manitoba or events of special interest to our community. The MLJ aims to bring diverse and multidisciplinary perspectives to the issues it studies, drawing on authors from Manitoba, Canada and beyond. Its studies are intended to contribute to understanding and reform not only in our community, but around the world. Robson Crim is housed in Robson Hall, one of Canada's oldest law schools. Robson Crim has transformed into a Canada wide research hub in criminal law, with blog contributions from coast to coast, and f...
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Governing in the Shadows
This book traces three decades of securitization in Angola. As a governing strategy during war and peacetime, it muted the aspirations of those on opposing sides, distorted the state, emboldened elites and redefined the identity of Angolans. Through this lens, Paula Cristina Roque provides an original account of Angola's post-conflict state-building. Securitization protected the interests of President dos Santos, the ruling MPLA party and the elites supporting the regime. Angola's array of security forces and infrastructure provided an alternative to a fully functioning executive, at national, provincial and local levels. The intrusive way in which any form of dissent or activism was crushed...
