Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Aging and Age-Related Disorders From Molecular Mechanisms to Therapies
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evi...
Global host proteomic responses to virus infection
The field of virology has seen explosive growth in the past few decades. A large amount of effort has gone into successfully delineating virus evolution, genetic diversity, immunology, pathogenesis, structure, vaccine development, viral gene expression and genomic replication strategies. In addition, considerable recent work has been focusing on cellular responses to infection as well as how viruses may induce transformation and oncogenesis. Viruses are obligate intracellular parasites and thus absolutely dependent upon host cells. Not surprisingly, they often cause profound changes in cells, including apoptosis, death and signalling, to name a few perturbations. Thus, the molecular signals ...
Factors Affecting Neurological Aging
Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. - Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging - Features sections on the genetic components that influence aging and diseases of aging - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables
Cerebrospinal Fluid (CSF) Proteomics
This volume focuses on protein analysis, including a wide range of the use of mass spectrometry and other protein methods within neurobiological disciplines. Chapters cover topics such as cerebrospinal fluid (CSF) processing and biobanking; label-free quantitative proteomics; SWATH; top-down proteomics; and experimental strategies based on other –omics applied to CSF metabolome, lipidome, and microRNAome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cerebrospinal Fluid (CSF) Proteomics: Methods and Protocols is a valuable resource for graduate students and post-doctoral fellows interested in learning more about CSF proteotyping. It is also useful to established researchers seeking further insight into this growing field.
Rebellion Now and Forever
This book explores the origins, process, and consequences of forty years of nearly continual political violence in southeastern Mexico. Rather than recounting the well-worn narrative of the Caste War, it focuses instead on how four decades of violence helped shape social and political institutions of the Mexican southeast. Rebellion Now and Forever looks at Yucatán's famous Caste War from the perspective of the vast majority of Hispanics and Maya peasants who did not join in the great ethnic rebellion of 1847. It shows how the history of nonrebel territory was as dramatic and as violent as the front lines of the Caste War, and of greater significance for the larger evolution of Mexican society. The work explores political violence not merely as a method and process, but also as a molder of subsequent institutions and practices.
Current Proteomic Approaches Applied to Brain Function
This volume focuses on protein analysis covering a wide spectrum of the utility of mass spectrometry within neurobiological disciplines. The chapters in this book discuss label (iTRAQ, TMT, protein arrays) and label-free workflows (SWATH, MALDI Imaging, and label-free quantitation). Other chapters look at experimental strategies targeted to the identification and quantitation of specific lipids and post-translational modifications, as well as proteomic workflows that focus on characterization of subcellular proteomes. The last few chapters in the book describe various bioinformatics pipelines used to analyze the molecular data derived from high-throughput transcriptomic and proteomic experiments on brain tissue. The Neuromethods series offers chapters with key advice and procedure specifics to empower the readers to successfully achieve their own scientific and experimental goals. Thorough and comprehensive, Current Proteomic Approaches Applied to Brain Function is a valuable resource for graduate students and postdoctoral fellows interested in neuroproteomics, as well as researchers looking for further insight into the growing field of mass spectrometry in neuroscience.
Joaquín Fernández de Leiva Erdoíza: constituyente y legislador chileno en las Cortes de Cádiz (1810-1812) - Dos tomos
Joaquín Fernández de Leiva Erdoíza constituyó parte del reducido grupo de diputados que participaron en la Comisión de Constitución de Las Cortes posterior a la formación de la Primera Junta de Gobierno en Chile. Como nadie, abogó por la creación de un Estado español unitario, donde españoles y americanos habían de tener una entera igualdad política al alero normativo de una Constitución y luchó incesantemente por visibilizar el verdadero carácter de los procesos políticos que sucedían en América a principios del siglo XIX. La investigación, en dos tomos, nos invita a conocer la influencia y obra política del desconocido medio hermano de Manuel Rodríguez, una historia que ha sido silenciada por los clásicos próceres de la memoria nacional. El autor da a conocer la intervención de un hombre que, bajo la bandera hispanoamericana, se invistió de ideales y propuestas que marcaron un precedente y nuevo rumbo, sobre todo, en la declaración de independencia de Chile en 1818.
Neuropathology of Neurodegenerative Diseases
This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
Global Action Plan on Physical Activity 2018-2030
Regular physical activity is proven to help prevent and treat noncommunicable diseases (NCDs) such as heart disease stroke diabetes and breast and colon cancer. It also helps to prevent hypertension overweight and obesity and can improve mental health quality of life and well-being. In addition to the multiple health benefits of physical activity societies that are more active can generate additional returns on investment including a reduced use of fossil fuels cleaner air and less congested safer roads. These outcomes are interconnected with achieving the shared goals political priorities and ambition of the Sustainable Development Agenda 2030. The new WHO global action plan to promote phys...
