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Techniques in Prion Research
-There is an acceleration in prion disease research because of the spread of mad cow disease. -This book covers in vitro, cellular, and animal models adapted for the study of TSEs. -Includes bio-saftey procedures.
Panama to Patagonia: The Isthmian Canal and the West Coast Countries of South America
THE effect of the Panama Canal on the West Coast industrial development and the reciprocal influence of this South American progress on the waterway are economic facts. The citizen of the United States who would know the subject in a wider range than the mere gratification of his patriotic impulses and his national pride, should turn to the study of commercial geography, the potential political economy of unexploited natural resources. The European statesman, jealously watchful of trade conditions in the New World and the causes which modify them, will follow these channels without suggestion. Whether the digging of the Canal take ten, fifteen, or twenty years, does not affect its industrial...
PrPSc Prions: State of the Art
This book is a printed edition of the Special Issue "PrPSc prions: state of the art" that was published in Pathogens
Coronaviruses and Arteriviruses
Proceedings of the VIIth International Symposium held in Segovia, Spain, May 10-15, 1997
Neuroprotection
In this first book to cover model systems, molecular mechanisms and clinical trials all in one volume internationally renowned scientists and clinicians provide a comprehensive treatment of neuroprotective strategies for all important neurological disorders. Following an overview of neurodegenerative, traumatic, and ischemic disorders, the book goes on to cover in vitro and animal model systems as well as cellular and molecular mechanisms. An extremely helpful analysis of clinical studies explains reasons for their success and failure, and the whole is rounded off with a look at the current challenges and hopes for the development of effective treatment strategies in the future.
Amyloid Proteins
A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Liberals, Politics, and Power
Looking at the Latin American liberal project during the century of postindependence, this collection of original essays draws attention to an underappreciated dilemma confronting liberals: idealistic visions and fiscal restraints. Liberals, Politics, and Power focuses on the inventiveness of nineteenth-century Latin Americans who applied liberal ideology to the founding and maintenance of new states. The impact of liberalism in Latin America, the contributors show, is best understood against the larger backdrop of struggles that pitted regional demands against the pressures of foreign finance, a powerful church against a decentralized state, and aristocratic desire to retain privilege again...
