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Vitamin-dependent Multienzyme Complexes of 2-oxo Acid Dehydrogenases
This book summarises current data on the architecture, structure-function relationships, reaction mechanisms and active site coupling in multienzyme complexes of 2-oxo acid dehydrogenases. Special focus concerns the mechanisms of function and regulation of a multienzyme structure, additional to those inherent in its component enzymes. The overall physiological process of 2-oxo acid oxidative decarboxylation and the substrate specificity determinants are considered along with side reactions of regulatory significance, such as non-oxidative reactions, formation of reactive oxygen species (ROS) and complex-bound thiyl radicals. The significance of the chemical interplay between the complex-boun...
Cellular Organelles and the Extracellular Matrix
This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistarget...
Scents that matter - from olfactory stimuli to genes, behaviors and beyond
Scents can carry a lot of important information about the environment, conspecifics and other species. While some of these scents are positively related, as the odor of food, mating partners, or familiar conspecifics, other scents are associated with negative situations and events, e.g. the occurrence of a predator, an aggressive territorial conspecific or spoiled food. The present research topic is focused on such “scents that matter”, i.e., scents that are crucial for the survival of an organism. Since many years, the importance of scents always attracts scientists to investigate how scents affect the behavior of mammals, via which mechanisms scents are perceived and how scents modulat...
