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Biological Reactive Intermediates
The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate...
Advances in DNA Damage and Repair
In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Role of Melatonin and Pineal Peptides in Neuroimmunomodulation
Research related to the pineal gland has advanced rapidly in the last three decades since the discovery of its most important hormone, melatonin. This indoleamine has been shown to have a large variety of effects in the organism; the bulk of these actions were initially thought to relate the pineal gland to the reproductive and endocrine systems. It is now apparent, however, that the physiologic interactions of the pineal and its hormones far transcend its control of endocrine function. One field of pineal research that has developed rapidly within the last 5 years has been the demonstration of its relationship to the immune system. Since the pineal gland is part of the central nervous syste...
Cytochrome P450 Protocols
In Cytochrome P450 Protocols, Ian Phillips and Elizabeth Shephard assemble a comprehensive collection of cutting-edge techniques for the investigation of cytochromes P450. Described in detail by hands-on experimentalists for easy reproducibility, these methods include spectral analysis, purification and enzymatic assays, expression in heterologous systems, and the production and use of antibodies, as well as methods for quantification of gene expression, transfection of hepatocytes, and for the investigation of DNA-protein interactions and genetic polymorphisms. In addition, because of the growing importance of in vitro systems in pharmacological toxicology, the book contains techniques for ...
Alcoholism: A Molecular Perspective
This book contains selected proceedings from the NATO Advanced Study Institute (AS I) "The Molecular Pathology of Alcoholism" held at the Hotel Il Ciocco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem and that the total cost to the economy of alcohol abuse is $117 billion. Treatment of alcohol dependence and other alcohol-related disorders accounts for almost 15% of the total health bill of the United States. Despite the scale of the medical problem, biome...
