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The Weekly Notes
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The Navy List
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Coolie Woman
In 1903 a Brahmin woman sailed from India to Guyana as a 'coolie', the name the British gave to the million indentured labourers they recruited for sugar plantations worldwide after slavery ended. The woman, who claimed no husband, was pregnant and travelling alone. A century later, her great-granddaughter embarks on a journey into the past, hoping to solve a mystery: what made her leave her country? And had she also left behind a man? Gaiutra Bahadur, an American journalist, pursues traces of her great-grandmother over three continents. She also excavates the repressed history of some quarter of a million female coolies. Disparaged as fallen, many were runaways, widows or outcasts, and many...
Blue Book
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Autophagy in Infection and Immunity
Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (s...
