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Present-day respiratory physiology stems largely from the explosion of ideas which took place during and after World War II. A number of the major players are still active, but the opportunity to prepare a personal history of this branch of medicine will soon be lost. In a sense then, this book offers an exceptional, even unique, opportunity. We are offered a first-hand chronicle of the advancements made in respiratory physiology in the course of this century by one of the principal figures in the field. The volume covers every aspect of the evolution of this important area of knowledge: morphology, gas exchange and blood flow, mechanics, control of ventillation, and comparative physiology. Some of the chapters are personal accounts of the development of respiratory physiology as observed by the author. It is hoped that what is lost in objectivity by this approach is more than made up by the captivating insights provided by the author into the process of scientific research and discovery.
This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications...
I organized this book because there is a need to put together in book form recent advances in our knowledge of how airway smooth muscle:works in health and in disease. After a period when it seemed that progress was very slow, there has been in the past few years an incredibly rapid gathering of knowledge in this area. In particular, our understanding has improved regarding the cascades of events that follow the initial binding of agonist to plasma membrane receptors and that lead to the cross-bridge movements that determine contraction. This advance in our knowledge was stimulated by use of single-and whole-cell channel recordings of plasma membrane currents and by description of the l3-rec...
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This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice. The book also provides insights into cough’s features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored. Coughing is a common symptom, occurring in many clinical settings, and as such the book appeals a broad readership, including pulmonologists specialized in cough, general practitioners, internists, pediatricians and otorhinolaryngologists.