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Perspectives in Molecular Toxinology
Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins. Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites. In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.
Silencing The Self
"This book is relevant to anyone grappling with the central challenge of relationships: how to achieve connections to others without losing oneself."--Deborah Tannen (author of You Just Don't Understand), New York Times Book Review
Profiling Domestic Violence
"This study uses household and individual-level data from the Demographic and Health Surveys (DHS) program to examine the prevalence and correlates of domestic violence and the health consequences of domestic violence for women and their children. Nationally representative data from nine countries - Cambodia (2000), Colombia (2000), the Dominican Republic (2002), Egypt (1995), Haiti (2000), India (1998-1999), Nicaragua (1998), Peru (2000), and Zambia (2001-2002) - are analyzed within a comparative framework to provide a multifaceted analysis of the phenomenon of domestic violence"--P. xv.
Colombia Before Independence
This book describes and analyzes economic and political developments in Colombia during the final century of Spanish rule. Its purpose is threefold: first, to provide a general portrait of Colombian society during the late colonial period, showing the character of economic, social, and political life in the territory's principal regions; second, to assess the impact on the region of European imperialist expansion during the eighteenth century; and third, to provide a context for understanding the causes of independence. The book offers the only available survey of Colombian history and historiography for this period.
Yeast
Yeast is one of the oldest domesticated organisms and has both industrial and domestic applications. In addition, it is very widely used as a eukaryotic model organism in biological research and has offered valuable knowledge of genetics and basic cellular processes. In fact, studies in yeast have offered insight in mechanisms underlying ageing and diseases such as Alzheimers, Parkinsons and cancer. Yeast is also widely used in the lab as a tool for many technologies such as two-hybrid analysis, high throughput protein purification and localization and gene expression profiling. The broad range of uses and applications of this organism undoubtedly shows that it is invalubale in research, technology and industry. Written by one of the world's experts in yeast, this book offers insight in yeast biology and its use in studying cellular mechanisms.
Myc as a Disease Target Beyond Cancer
Myc is a pleiotropic transcription factor fundamental for many cellular processes. It is an infamous and highly-studied oncogene, with around 10,000 articles published in the last decade. The majority of these link it to cancer. The focus on Myc as a hot target in cancer has led to immense efforts – from academia through to pharmaceutical companies – being directed towards finding a Myc inhibitor. Not surprisingly, given its fundamental nature in many physiological processes, Myc has also been linked to a large variety of pathologies other than cancer. The growing efforts to develop Myc inhibitors as cancer therapies will have important implications for the treatment of these diseases to...
Chromatin Structure and Dynamics
Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.
Dog Behaviour, Evolution, and Cognition
This is the first book to collate and synthesize the recent burgeoning primary research literature on dog behaviour, evolution, and cognition. The author presents a new ecological approach to the understanding of dog behaviour, demonstrating how dogs can be the subject of rigorous and productive scientific study without the need to confine them to a laboratory environment. This second, fully updated edition of Dog Behaviour, Evolution and Cognition starts with an overview of the conceptual and methodological issues associated with the study of the dog, followed by a brief description of their role in human society. An evolutionary perspective is then introduced with a summary of current rese...
Handbook of Gravitational Wave Astronomy
This handbook provides an updated comprehensive description of gravitational wave astronomy. In the first part, it reviews gravitational wave experiments, from ground and space based laser interferometers to pulsar timing arrays and indirect detection from the cosmic microwave background. In the second part, it discusses a number of astrophysical and cosmological gravitational wave sources, including black holes, neutron stars, possible more exotic objects, and sources in the early Universe. The third part of the book reviews the methods to calculate gravitational waveforms. The fourth and last part of the book covers techniques employed in gravitational wave astronomy data analysis. This book represents both a valuable resource for graduate students and an important reference for researchers in gravitational wave astronomy.
