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Chemical Linkers in Antibody-Drug Conjugates (ADCs)
Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.
John Lambert, Parliamentary Soldier and Cromwellian Major-general, 1619-1684
The biography of one of the most prominent soldiers in the New Model Army, John Lambert (1619-1684) who made Cromwell Lord Protector but prevented him from becoming king.
Flower Class Corvettes
A guide to creating models of the World War II warship, featuring history on the ship as well as crafting tips. The “ShipCraft” series provides in-depth information about building and modifying model kits of famous warship types. Lavishly illustrated, each book takes the modeler through a brief history of the subject class, highlighting differences between sister-ships and changes in their appearance over their careers. This includes paint schemes and camouflage, featuring color profiles, highly detailed line drawings, and scale plans. The modelling section reviews the strengths and weaknesses of available kits, lists commercial accessory sets for super-detailing of the ships, and provid...
Cytotoxic Payloads for Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages includ...
Fairmile 'D' Motor Torpedo Boat
The Fairmile Type D was designed to combat the known advantages of German S-boats (Schnellboote - but always called 'E-boats' by the Allies) over previous British coastal craft designs. Designed for 31 knots at 80 tons' displacement, the Fairmile Ds were the most potent and heavily-armed coastal forces type of any navy. They fulfilled various roles, from the original MTB/MGB role to anti-submarine and mine operations. This book is the most comprehensive body of information available anywhere in a single volume on this important type. This book provides the finest documentation of these uniquely fast small warships ever produced, through a complete set of superbly executed line drawings offering enthusiasts a novel insight into ship design and construction. In addition, it includes a service and design history and a pictorial section emphasising close-up and on-board photographs.
A Genealogical and Heraldic Dictionary of the Landed Gentry of Great Britain and Ireland
Reprint of the original, first published in 1858. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
Allied Coastal Forces of WWII, Volume 1
The first volume in this series detailing all the designs for Motor Torpedo Boats, Motor Gun Boats and Motor Launches that served the Allied Forces in the period 1939-45. It covers all the designs of the British Fairmile Marine Company (including those craft built and equipped in Canada), together with the 72ft Admiralty harbor Defence Motor Launch designs and the US Navy's 110ft submarine chaser. Separate sections deal with Coastal Forces armament and equipment in full, and appendices include further technical detail, production data, provisioning and typical service records.
