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Tumor Suppressor Genes
It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and ...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Human Retrotransposons in Health and Disease
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.
Cellular Senescence and Tumor Suppression
As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Gene Targeting
Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first chapter covers the design of gene targeting vectors for mammalian cells and describes how to distin...
Pandora's Box
This book is about the coronavirus and the pandemic it spawned, and what this outbreak means for future pandemics. It analyses the official response and sees where improvements can be made, for example, the World Health Organization waited till March to designate the coronavirus a pandemic and a full year before confirming its airborne transmission. The book looks at the specific nature of the virus, its origins and how it was transmitted, why it was so deadly to predisposed individuals, how it compares to previous pandemics, what measures were taken mitigate the disease and how to protect ourselves against it in future. The book also looks into the wider implications of the pandemic and its...
Memory Speaks
From an award-winning writer and linguist, a scientific and personal meditation on the phenomenon of language loss and the possibility of renewal. As a child Julie Sedivy left Czechoslovakia for Canada, and English soon took over her life. By early adulthood she spoke Czech rarely and badly, and when her father died unexpectedly, she lost not only a beloved parent but also her firmest point of connection to her native language. As Sedivy realized, more is at stake here than the loss of language: there is also the loss of identity. Language is an important part of adaptation to a new culture, and immigrants everywhere face pressure to assimilate. Recognizing this tension, Sedivy set out to un...
