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The Claustrum
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integ...
The Law Reports
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The Law Reports
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The Law Reports
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A Pleasing Prospect
Based on extensive primary-source research, this historical account considers the changing identity of 18th-century Colchester from the perspective of its "middling sort"--a section of society often attached to cultures of politeness and to the practices of consumption and production that helped shape economic change. Painstakingly reconstructing 18th-century social networks along lines of family, kinship, gender, spatiality, religion, and politics, this study examines the relationships between individual and family biographies while reflecting on provincial urban society and culture. The guide explores how Colchester capitalized on growth in agriculturally based industries--such as brewing, milling, and malting--and its role as an east-coast port and its participating in the urban renaissance and commodification of polite culture.
The Neuromodulators
Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trig...
The Dynamic Neuron
A comprehensive review of current research on synaptic plasticity. The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.
