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The papers included in this volume provide a fascinating review of contemporary pathology, diagnostic techniques, management approaches and pharmacological interventions. They are based on the popular Advanced Medicine conference organised annually by the Royal College of Physicians which aims to present 'the latest cutting edge advances in clinical medicine, supported by improved understanding of disease mechanisms'. Each chapter, by an eminent physician from one of a variety of specialties included, is followed by self-assessment questions, which allow the reader to ensure they have fully absorbed and correctly understood the chapter's key messages. Whether the reader's specific interest lies in, for example, 'Attacking the disease spiral in COPD', New drugs for diabetes' or Advances in Parkinson's disease' - to name but a few of the topics covered - the remainder of the book will provide them with an informative summary of advances in other fields of medicine.
This book is a complete guide to gastrointestinal diseases and disorders for trainees in gastroenterology. Sixteen sections each cover a different symptom, explaining signs, clinical features, investigation methods, differential diagnosis and treatment. Topics include chronic abdominal pain, anorectal problems, gastrointestinal bleeding, eating disorders, jaundice, abdominal masses, liver failure, and much more. Authored by Consultant Gastroenterologist Her Hsin Tsai from Hull and East Yorkshire Hospitals NHS Trust, this practical text is further enhanced by more than 350 clinical photographs, radiological images, diagrams and tables to assist learning. Key points Complete guide to gastrointestinal diseases and disorders for trainees Covers many different symptoms, their clinical features, investigation, differential diagnosis and treatment Authored by recognised Hull-based Consultant Gastroenterologist Highly illustrated with clinical photographs, radiological images, diagrams and tables
The second edition of Clinical Dilemmas in Inflammatory Bowel Disease: New Challenges, is a practical, up-to-date handbook providing expert guidance on specific clinical dilemmas and areas of difficulty that the gastroenterologist regularly faces in day-to-day practice. In this new edition, 75% of the “dilemmas” are brand new dilemmas facing the IBD specialist concerning emerging treatment therapies, such as the use of cannabinoids and Viagra for Crohn’s disease. The remaining 25% of the dilemmas are fully updated from the previous edition, incorporating the latest clinical thinking. Each of the 57 evidence-based chapters contains clear learning points, addresses different topics, and provides sound guidance on subjects ranging from optimizing current management through to special management problems and novel treatments. This book is suitable for all medical professionals involved in the care of patients with IBD: established and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, specialist nurses, pharmacists, dieticians and counselors.
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This book examines the electoral successes of anti-system forces in the rich democracies. It explains the rise of anti-system politicians and parties in terms of two separate but closely related developments: the rise of economic inequality and insecurity over the last four decades, and the failure of political elites to address them.
Now fully updated and considerably expanded, Glycoanalysis Protocols, 2nd ed., makes available to all protein scientists, and particularly those working with today's pharmaceuticals, the most advanced and reproducible glycoanalysis techniques currently in use. Developed by highly experienced carbohydrate chemists, biochemists, and physical chemists, these detailed, up-to-date, and proven analytical techniques cover the areas of glycoprotein macromolecular structural analysis, oligosaccharide profiling, lipid conjugate characterization, microorganism structure determination, and proteoglycan function. Special attention has been given to advanced analytical techniques in biotechnology during the production of recombinant glycoproteins and other therapeutics. Hailed as "indispensable" in its first edition, Glycoanalysis Protocols, 2nd ed., continues with vital, time-tested techniques addressing the needs of both biomedical researchers and protein macromolecular structural chemists. It will well serve all those starting work on the analysis of glycoproteins, as well as more experienced investigators seeking to augment their expertise.
Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the “magic bullet” that would allow the specific destruction of neoplastic cells. H- ever, many years’ effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed ...