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Nitric Oxide in Health and Disease
Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a ...
Nitric Oxide and Cancer: Pathogenesis and Therapy
Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.
Nitric Oxide, Part F
The discovery that nitrogen monoxide or nitric oxide (NO)is a biologically produced free radical has revolutionized our thinking about physiological and pathological processes. This discovery has ignited enormous interest in the scientific community. When generated at low levels, NO is a signaling molecule, but at high concentration, NO is a cytotoxic molecule. The physiological and pathological processes of NO production and metabolism and its targets, currently areas of intensive research, have important pharmacologic implications for health and disease.
Mediterranean Seafarers in Transition
This volume discusses the effects of industrialization on maritime trade, labour and communities in the Mediterranean and Black Sea from the 1850s to the 1920s. The 17 essays are based on new evidence from multiple type of primary sources on the transition from sail to steam navigation, written in a variety of languages, Italian, Spanish, French, Greek, Russian and Ottoman. Questions that arise in the book include the labour conditions, wages, career and retirement of seafarers, the socio-economic and spatial transformations of the maritime communities and the changes in the patterns of operation, ownership and management in the shipping industry with the advent of steam navigation. The book offers a comparative analysis of the above subjects across the Mediterranean, while also proposes unexplored themes in current scholarship like the history of navigation. Contributors are: Luca Lo Basso, Andrea Zappia, Leonardo Scavino, Daniel Muntane, Eduard Page Campos, Enric Garcia Domingo, Katerina Galani, Alkiviadis Kapokakis, Petros Kastrinakis, Kalliopi Vasilaki, Pavlos Fafalios, Georgios Samaritakis, Kostas Petrakis, Korina Doerr, Athina Kritsotaki, Anastasia Axaridou, and Martin Doerr.
Cohousing in Barcelona
Barcelona offers a prime example of the co-housing model as an asset prized for its use value as opposed to investment. This book is a compilation of cooperative housing projects in Barcelona, both complete and under construction. It explains how the co-housing process is managed in terms of architecture, urban planning, financing, legality, and taxation, and delves into the experience of living in a community fueled a cooperative spirit. The content of the book presents designs for cooperative housing, accompanied by a critical vision of the model’s implications in terms of the transfer of use or co-living. Finished and inhabited projects are compiled along with ongoing projects, to offer a general view of this way of living in Barcelona. The case studies are explained by members of cooperatives, experts and designers who look at aspects of design, sustainability, construction and urban life. This book is a tool for understanding the design and construction of co-housing and the community life that goes on there.
Cities of Strangers
Cities of Strangers illuminates life in European towns and cities as it was for the settled, and for the 'strangers' or newcomers who joined them between 1000 and 1500. Some city-states enjoyed considerable autonomy which allowed them to legislate on how newcomers might settle and become citizens in support of a common good. Such communities invited bankers, merchants, physicians, notaries and judges to settle and help produce good urban living. Dynastic rulers also shaped immigration, often inviting groups from afar to settle and help their cities flourish. All cities accommodated a great deal of difference - of language, religion, occupation - in shared spaces, regulated by law. When this ...
Pandemic Disease in the Medieval World
The plague organism (Yersinia pestis) killed an estimated 40% to 60% of all people when it spread rapidly through the Middle East, North Africa, and Europe in the fourteenth century: an event known as the Black Death. Previous research has shown, especially for Western Europe, how population losses then led to structural economic, political, and social changes. But why and how did the pandemic happen in the first place? When and where did it begin? How was it sustained? What was its full geographic extent? And when did it really end?
