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Mucosal Delivery of Biopharmaceuticals
Biopharmaceutical medicines, the newest class of therapeutics, are quite heterogeneous and include a range of molecules such as proteins, peptides, vaccines and nucleic acids, with use in virtually all therapeutic fields (e.g. cancer and infectious diseases, vaccination, metabolic dysfunctions) and diagnostics. This edited book gives a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals, the technological strategies that have been followed so far regarding the optimization of mucosal potentialities as well as the challenges that arise with the advent of new biopharmaceutical drugs and alternative me...
Biomedical Applications of Functionalized Nanomaterials
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section...
Concepts and Models for Drug Permeability Studies
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biolo...
Marcello Caetano and the Portuguese New State
Prime Minister Marcello Caetano was the successor of Antonio de Oliveira Salazar. Considered the second most important figure of the Portuguese dictatorship (the Estado Novo regime, 1933-1974), Caetano has generated considerable disagreement amongst scholars with regard to his persona and politics; some consider him more authoritarian than his predecessor, others more liberal. After providing background on his childhood and entry to university, the author explains his growing activism in the Integralismo Lusitano and in the Catholic Church; his monarchist and nationalist ideology. Caetano's decision to support the Salazar Regime coincided with publications in the mainstream media on corporat...
Novel Approaches for the Delivery of Anti-HIV Drugs
HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.
Chitosan-Based Systems for Biopharmaceuticals
Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals w...
Brazil and the Struggle for Rubber
Brazil once enjoyed a near monopoly in rubber when the commodity was gathered in the wild. By 1913, however, cultivated rubber in South-east Asia swept the Brazilian gathered product from the market. In this innovative study, Warren Dean demonstrates that environmental factors have played a key role in the many failed attempts to produce a significant rubber crop again in Brazil. In the Amazon attempts to shift to cultivated rubber failed repeatedly. Brazilian social and economic conditions have been blamed for these failures, in particular the failure of local capitalists and the refusal of the working class to accept wage labour. Dean shows in this study, however, that the difficulty was mainly ecological: the rubber tree in the wild lives in close association with a parasitic leaf fungus; when the tree was planted in close stands, the blight appeared in epidemic proportions.
Drug Delivery and Development of Anti-HIV Microbicides
The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed. In the absence of a cure, prophylaxis represents a cornerstone in the battle against infection. One promising strategy comprises the use around the time of sexual intercourse of vaginal/rectal products containing antiviral compounds, termed microbicides. It is now recognized that specific development of drug ...
