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Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progr...
How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and c...
Backpacker brings the outdoors straight to the reader's doorstep, inspiring and enabling them to go more places and enjoy nature more often. The authority on active adventure, Backpacker is the world's first GPS-enabled magazine, and the only magazine whose editors personally test the hiking trails, camping gear, and survival tips they publish. Backpacker's Editors' Choice Awards, an industry honor recognizing design, feature and product innovation, has become the gold standard against which all other outdoor-industry awards are measured.
(Limelight). Irving Berlin marked the end of WWI with a show that opened on Broadway just before Armistice Day, 1918, and ran for all of 32 performances. Yip, Yip, Yaphank was notable for its company, made up entirely of servicemen. The idea of an all-service show resurfaced in the wake of the U.S. entry into WWII, and the cast of This Is the Army was rehearsing and preparing to open at New York's Broadway Theatre. Their story is recalled here by Alan Anderson, whose first assignment after induction into the service was to be production stage manager and first sergeant of the This Is the Army detachment. From this vantage point Anderson enjoyed a unique perspective on the show, on all the elements that went into it, and on all the personalities that in one way or another brought the elements to life.
The Irving Berlin Reader offers fascinating glimpses the life and work of this most famous of American songwriters. Berlin is presented here in full through writings from his earliest years to the present, including Berlin's own thoughts on songwriting. Many of the articles are otherwise difficult or impossible to find, and all are expertly contextualized by Ben Sears's introductions.
A detailed study of Isaiah Berlin: historian, philosopher, and political theorist. Situates his evolving ideas in the context of British society and world politics. Offers a new interpretation of Berlin's influential writings on liberty and his debts to philosophy, and makes clear his relationship to the political debates of his times.
In this penetrating exploration of contemporary Russia, Joshua Yaffa meets a variety of Russians - from politicians and entrepreneurs to artists and historians - who have built their careers and constructed their identities in the shadow of the Putin system. Torn between their own ambitions and the omnipresent demands of the state, each has found that compromise is essential for survival and success. Some extract benefits and privileges through cunning and cynicism, others less adept at navigating the system are left broken and demoralized. With sensitivity and depth, Yaffa profiles Russians from institutions such as the Bolshoi and Channel 1, from the major cities, and from regions such as Chechnya, post-annexation Crimea, and the Urals, including an Orthodox priest at war with the church hierarchy and a Chechen humanitarian who turns a blind eye to persecutions. The result is an intimate and probing portrait of a nation much discussed but little understood. And by showing how citizens shape their lives around the demands of a capricious and repressive state, Yaffa offers urgent lessons about the nature of modern authoritarianism.