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High Throughput Screening Methods
High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals ...
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Diversity-Oriented Synthesis
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical bi...
The Cambridge Companion to John Henry Newman
John Henry Newman (1801–90) was a major figure in nineteenth-century religious history. He was one of the major protagonists of the Oxford or Tractarian Movement within the Church of England whose influence continues to be felt within Anglicanism. A high-profile convert to Catholicism, he was an important commentator on Vatican I and is often called 'the Father' of the Second Vatican Council. Newman's thinking highlights and anticipates the central themes of modern theology including hermeneutics, the importance of historical-critical research, the relationship between theology and literature, and the reinterpretation of the nature of faith. His work is characterised by two elements that have come especially to the fore in post-modern theology, namely, the importance of the religious imagination and the fiduciary character of all knowledge. This Companion fills a need for an accessible, comprehensive and systematic presentation of the major themes in Newman's work.
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