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The Search for Antidepressants - An Integrative View of Drug Discovery
Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been...
Tratado de Psiquiatria da Associação Brasileira de Psiquiatria
O Tratado de psiquiatria da Associação Brasileira de Psiquiatria reúne destacados autores dos principais centros de pesquisa e formação de todo o País para trazer aos leitores em língua portuguesa os conhecimentos mais atuais na área.Sob a organização dos doutores Antonio Egidio Nardi, Antônio Geraldo da Silva e João Quevedo, este livro, disponível nos formatos impresso e e-book, é composto por 46 capítulos que abordam desde os fundamentos da área – abrangendo temas como história da psiquiatria, ética, a relação entre religiosidade, espiritualidade e transtornos mentais, epidemiologia, estatística, sistema de saúde, estigma e psicofobia, o desenvolvimento normal, aspe...
Understanding Depression
This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.
Psiquiatria Intervencionista
Abordagem nova para o tratamento dos transtornos mentais, a psiquiatria intervencionista abrange múltiplos procedimentos técnicos – como, por exemplo, diferentes tipos de estimulação cerebral e procedimentos guiados por neuroimagem –, todos em rápida evolução e expansão. Neste livro, os doutores Andre R. Brunoni, Clement Hamani e João Quevedo reuniram destacados profissionais da psiquiatria para trazer ao público brasileiro o que há de mais atual na área. Os leitores encontrarão, entre outros tópicos, capítulos que abrangem desde o surgimento das técnicas até as diferentes aplicações da neuromodulação, das convulsoterapias e da estimulação do nervo vago; uma proposta de currículo para a psiquiatria intervencionista; o uso de gases anestésicos, quetamina e psicodélicos; a cirurgia psiquiátrica, bem como aspectos neuroéticos da neuromodulação.
The Silver Branch and the Otherworld
• Shares insights from herbalism, ecology, neurobiology, psychology, Irish history, and magical tradition to show how to tap into the flow of communication from the wild world • Explores the seven principles of animist herbalism and the ancient Irish understanding of the “three cauldrons” of the body, showing how they can be applied to the practice of modern herbalism • Introduces thirteen important plant and fungi allies and provides simple practices for deepening your connections with wild plants and your ancestors To our ancestors, the wild world around them was filled with meaning, guidance, and insight. They recognized the symbols hidden in Nature that represent invitations to...
Bipolar Disorder: From Neuroscience to Treatment
Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry. Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously. With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.
Sex with a Brain Injury
For readers of Meghan O’Rourke’s The Invisible Kingdom, Esme Weijun Wang’s The Collected Schizophrenias, and Melissa Febos’s Girlhood, a powerful and deeply personal memoir in essays that sheds light on the silent epidemic of head trauma. Annie Liontas suffered multiple concussions in her thirties. In Sex with a Brain Injury, she writes about what it means to be one of the “walking wounded,” facing her fear, her rage, her physical suffering, and the effects of head trauma on her marriage and other relationships. Forced to reckon with her own queer mother’s battle with addiction, Liontas finds echoes in their pain. Liontas weaves history, philosophy, and personal accounts to int...
Treatment Resistance in Psychiatry
This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.
Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders
This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders
This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
