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The Physiology of Truth
In this wide-ranging book, one of the boldest thinkers in modern neuroscience confronts an ancient philosophical problem: can we know the world as it really is? Drawing on provocative new findings about the psychophysiology of perception and judgment in both human and nonhuman primates, and also on the cultural history of science, Jean-Pierre Changeux makes a powerful case for the reality of scientific progress and argues that it forms the basis for a coherent and universal theory of human rights. On this view, belief in objective knowledge is not a mere ideological slogan or a naive confusion; it is a characteristic feature of human cognition throughout evolution, and the scientific method its most sophisticated embodiment. Seeking to reconcile science and humanism, Changeux holds that the capacity to recognize truths that are independent of subjective personal experience constitutes the foundation of a human civil society.
Epigenetics, Brain and Behavior
Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.
Cellular and Molecular Control of Direct Cell Interactions
The NATO Advanced Study Institute on "Cellular and Molecular Control of Direct Cell Interactions in Developing System" has been attended by 15 invited main lecturers and 60 participants. According to its purpose senior scientists, postdoctoral trainees and graduate students working in areas like biology, biochemistry, electrophysiology, medicine etc . . . could discuss their common interest in the various structural, ultrastructural, molecular and functional aspects of cell interactions in developing in vivo and in vitro systems. Whereas the topics of the first week have been mostly concerned with the general aspects of cell interactions in embryogenesis (section I and II of this book), the ...
International Review of Neurobiology
International Review of Neurobiology
Molecules in Physics, Chemistry, and Biology
Volume 1: General Introduction to Molecular Sciences Volume 2: Physical Aspects of Molecular Systems Volume 3: Electronic Structure and Chemical Reactivity Volume 4: Molecular Phenomena in Biological Sciences
Neuronal Man
Over the past thirty-five years, there has been an explosive increase in scientists' ability to explain the structure and functioning of the human brain. While psychology has advanced our understanding of human behavior, various other sciences, such as anatomy, physiology, and biology, have determined the critical importance of synapses and, through the use of advanced technology, made it possible actually to see brain cells at work within the skull's walls. Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our understanding in the twentieth century.
Molecules in Physics, Chemistry, and Biology
Volume 1: General Introduction to Molecular Sciences Volume 2: Physical Aspects of Molecular Systems Volume 3: Electronic Structure and Chemical Reactivity Volume 4: Molecular Phenomena in Biological Sciences
Brain Development
This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic regulation. Another common neurotoxin is nicotine, and it is discussed in this book for three reaso...
Molecular Biology of Neuroreceptors and Ion Channels
This workshop was the second of this series held on the island of santorini in the Cycladic Sea. The first one ("Mechanism of Action of the Nicotinic Acetylcholine Receptor", NATO ASI Se ries H, vol. 10) took place in May 1986 and focused on what was at the time the best studied of all neuroreceptors. This second one, held only two years later, demonstrates the im mense progress achieved since then in the field of neurorecep tors and ion channels. Molecular cloning techniques have now made available the primary structures of a whole array of ion channel proteins, and this in turn has shed light on some gen eral principles of the structure-function relationships of these central elements of intercellular communication. The purpose of this workshop was to explore the common ele ments in gene and protein structure of already cloned ion channel proteins, and to assess the status of other cloning projects in progress. It explicitly focused on very recently published and unpublished results. All participants kept to these goals thereby demonstrating the very value of such work shops for the progress of science.
Myasthenia Gravis
Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune...
