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The series is devoted to the publication of high-level monographs, surveys and proceedings which cover the whole spectrum of computational and applied mathematics. The books of this series are addressed to both specialists and advanced students. Interested authors may submit book proposals to the Managing Editor or to any member of the Editorial Board. Managing EditorUlrich Langer, Johannes Kepler University Linz, Austria Editorial BoardHansj rg Albrecher, University of Lausanne, SwitzerlandRonald H. W. Hoppe, University of Houston, USAKarl Kunisch, RICAM, Linz, Austria; University of Graz, AustriaHarald Niederreiter, RICAM, Linz, AustriaChristian Schmeiser, University of Vienna, Austria
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
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Although the physiology of the menstrual cycle appears clear and easily explained by a balance in the concentration of various sex steroid hormones, numerous details of its mechanism are still poorly understood and little is known about the relationship among clinical events, plasma hormone concentrations, molecular impacts on target tissues and their regulation. In the following chapters, the authors have attempted to establish a correlation between endometrial histology and well-understood physiologic events of the menstrual cycle. They have provided up-to-date information on the effects of various hormones and combinations of hormones on the endometrium. The interdependence of endometrial...
It is clear today that several prostaglandins play an important role in the regulation of many of the physiological events of the reproductive organs in the human. Both naturally occurring prostaglandins and their analogues are used routinely in many countries to ripen the cervix and induce labour at term as well as to dilate the cervix and to terminate pregnancy. Prostaglandin biosynthesis inhibitors are widely used in the treatment of primary dysmenorrhoea. The editors have aimed at an accurate, thorough, yet easily under standable review of the status in 1986 of medical knowledge regarding both the physiological importance and the clinical use of prostaglan dins and their inhibitors in ob...
This book provides practicing pathologists, dermatologists, cutaneous oncologists and dermatopathologists with a reference textbook that reviews the clinical and histopathologic features of skin disorders that affect children, along with a discussion of the molecular pathogenesis for each disease as it is currently known. The book includes a concise discussion of the clinical presentation, as well as the histologic and, when appropriate, immunohistochemical features of each disease. The book is divided into two main sections, non-neoplastic and neoplastic skin diseases. Each section is comprised of a series of chapters organized according to histologic findings rather than by clinical classi...
The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules. The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filamen...
Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.