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The Mathematical Legacy of Eduard Čech
The work of Professor Eduard Cech had a si~ificant influence on the development of algebraic and general topology and differential geometry. This book, which appears on the occasion of the centenary of Cech's birth, contains some of his most important papers and traces the subsequent trends emerging from his ideas. The body of the book consists of four chapters devoted to algebraic topology, Cech-Stone compactification, dimension theory and differential geometry. Each of these includes a selection of Cech's papers, a brief summary of some results which followed from his work or constituted solutions to the problems he posed, and several selected papers by various authors concerning the areas of study he initiated. The book also contains a concise biography borrowed with minor changes from the book Topological papers of E. tech, a list of Cech's publications and a very brief note on his activity in the didactics of mathematics. The editors wish to express their sincere gratitude to all who contributed to the completion and publication of this book.
The Stone-Čech Compactification
Recent research has produced a large number of results concerning the Stone-Cech compactification or involving it in a central manner. The goal of this volume is to make many of these results easily accessible by collecting them in a single source together with the necessary introductory material. The author's interest in this area had its origin in his fascination with the classic text Rings of Continuous Functions by Leonard Gillman and Meyer Jerison. This excellent synthesis of algebra and topology appeared in 1960 and did much to draw attention to the Stone-Cech compactification {3X as a tool to investigate the relationships between a space X and the rings C(X) and C*(X) of real-valued c...
Telomeres and Telomerase in Cancer
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Chemistry, 1981-1990
A collection of the Nobel Lectures delivered by the prizewinners in chemistry, together with their biographies, portraits and the presentation speeches.
The Cerebrospinal Fluid in Severe Pain Conditions: Clinical, Pharmacological and Proteomic Aspects
The treatment of both cancer pain and non-cancer chronic pain is still suboptimal. The overall aim of this PhD thesis was to conduct translational pain research at the interface between clinical pain medicine and the field of human proteomics, using the practice of intrathecal analgesia at our institution as a starting point. Hence, the cerebrospinal fluid (CSF) is at the centre of the present dissertation, both as a target for infusing analgesics (Papers I and II – clinical and pharmacological aspects) and as an important biofluid for human biomarker studies (Papers III and IV – proteomic aspects). In Paper I, 28 cases of intrathecal analgesia in cancer patients were prospectively follo...
Using Mass Spectrometry for Drug Metabolism Studies
Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field. Using Mass Spectrometry
