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Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called connexins (Cxs). It is well known that GJCs are involved in several functions, such as intercellular propagation of calcium waves, spread of electrotonic potentialsand spatial buffering of ions and metabolites. On the other hand, undocked hemichannels, which are not forming GJCs, can also serve other functions as “free hemichannels”. Currently, it...
Given that the extremely elaborated and dynamic functions performed by the nervous system require the close synchronization of brain cells, complex organisms have developed different mechanisms of intercellular communication. At this regard, paracrine signaling between neighboring cells is currently recognized as one of the most widely distributed mechanisms of synchronization in the brain parenchyma. In mammals, paracrine signaling is in part mediated by single membrane channels formed by connexins (connexons/hemichannels) or pannexins (pannexons), which are two different membrane protein families composed of about 20 and 3 members, respectively. Single membrane channels formed by these pro...
Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glia...
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular ...
Lysts using enzyme, microbial, and plantbiochemistriesand genetic engi neeringand "ProcessingResearch" describedtheconversionofplantcom ponentsviaintegrationofmicrobiology, biochemistry, andchemistrywith engineering, separations, and hybrid systems. The "Enzymatic Processes and Enzyme Production" session focused on the manufacture and use of enzymes. The"IndustrialChemicals"sessionemphasizedrecentdevelop mentsintheintegratedproductionandscale-upofchemicalsfrombiologi cal rather than petrochemical routes. Special interest was on separation methods and their integrationintonew fermentation orhybrid processes. 35 oral presentations, a roundtable The technical program consisted of forum, two spe...
An exercise in Open Philosophy -- a worldview open to the full range of human experience including science, spirituality and traditional philosophy. Naturalism is exposed as a closed, a priori worldview. God is not an alternative to, but the completion of, scientific explanation. The foundations and data of evolution do not show randomness, but Mind in nature. Evolution aims at verifiable targets and develops means in advance of need. While God is proven deductively, the fine-tuning argument makes a strong case despite the anthropic principle. The rules of evidence are discussed critically before reviewing data on mind ranging from neuroscience, connectionism, & cybernetics to introspection, parapsychology, near death experiences & mysticism -- even I-Thou relationships. Current theories are inadequate to important data points. Traditional philosophy suggests a single substance, two-subsystem theory integrating a data processing brain and an intentional, immaterial soul to solve the mind-body problem.
The objective in editing this volume was twofold: to provide a reasoned overview of the field as well as to furnish one that provided this overview within the context of the intellectual boundaries of those who initially attempted to define the purview of gap junction research. The latter objective has been realized by selecting the topics for review in this volume. The former objective was achieved by securing the cooperation of leaders in their fields as chapter co-authors.
This book emphasizes past and current research efforts about principles of natural control of major parasites affecting humans, animals, and crops. Each chapter is a complete and integrated subject that presents a problem and confers on the safe alternatives to chemicals. This book discusses and updates information about three major topics of natural remedies. The first topic is represented in a chapter outlining important information on biological control of parasites, the second topic is represented in three chapters dealing with botanicals as promising antiparasitic agents, and the last four chapters deal with miscellaneous control strategies against parasites. This easily readable book is designed precisely for students as well as professors linked with the field of parasitic control. We enhanced words with breathing areas in the form of graphical abstracts, figures, photographs, and tables.