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Morphogens in the Wiring of the Nervous System
Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules that regulate tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system.
Neurodegenerative Diseases
This book discusses in detail the different hypothesis and experimental evidence regarding the neurobiological mechanisms involved in neurodegenerative pathology, with an emphasis in Alzheimer's and Parkinson's disease. Since there are many hypotheses for neurodegenerative diseases, there is a real need for a comprehensive view, allowing for integration of the different views for the pathogenic mechanisms of the disease.
Encyclopedia of Latin American History and Culture
Strives to organize knowledge of the region. It contains nearly 5,300 separate articles. Most topics appear in English alphabetical order.
Contested Markets, Contested Cities
Markets are at the origin of urban life as places for social, cultural and economic encounter evolving over centuries. Today, they have a particular value as mostly independent, non-corporate and often informal work spaces serving millions of the most vulnerable communities across the world. At the same time, markets have become fashionable destinations for ‘foodies’ and middle class consumers and tourists looking for authenticity and heritage. The confluence of these potentially contradictory actors and their interests turns markets into "contested spaces". Contested Markets, Contested Cities provides an analytical and multidisciplinary framework within which specific markets from Mexico City, Buenos Aires, Santiago de Chile, Quito, Sofia, Madrid, London and Leeds (UK) are explored. This pioneering and highly original work examines public markets from a perspective of contestation looking at their role in processes of gentrification but also in political mobilisation and urban justice.
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