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After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data. Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data Uses up-to-date methods to exploit omic data Presents methods through specific examples and computing sessions Supplemented by a website, including code, datasets, and solutions
Diesel engines, also known as CI engines, possess a wide field of applications as energy converters because of their higher efficiency. However, diesel engines are a major source of NOX and particulate matter (PM) emissions. Because of its importance, five chapters in this book have been devoted to the formulation and control of these pollutants. The world is currently experiencing an oil crisis. Gaseous fuels like natural gas, pure hydrogen gas, biomass-based and coke-based syngas can be considered as alternative fuels for diesel engines. Their combustion and exhaust emissions characteristics are described in this book. Reliable early detection of malfunction and failure of any parts in diesel engines can save the engine from failing completely and save high repair cost. Tools are discussed in this book to detect common failure modes of diesel engine that can detect early signs of failure.
This volume contains the proceedings of the Second International Symposium on Transition Metal Catalyzed Polymerizations held in 1986. The papers provide a broad-based perspective covering recent scientific and technological advances in Ziegler-Natta and metathesis polymerization, including olefin, diene, and acetylene polymerization, and copolymerization. The emphasis on reaction kinetics of polymerizations in different reagent and catalyst environments makes this volume of interest to both academic and industrial researchers.
Research on the relationship between health and the environment in a postgenomic context is increasingly aimed at understanding the various exposures as a whole, simultaneously taking into account data pertaining to the biology of organisms and the physical and social environment. Exposome research is a paradigmatic case of this new trend in environmental health studies. This book takes a multidisciplinary approach focusing on the conceptual, epistemological, and sociological reflections in the latest research on environmental and social determinants of health and disease. It offers a combination of theoretical and practical approaches and the authors are scholars from a multidisciplinary background (epidemiology, geography, philosophy of medicine and biology, sociology). Crucially, the book balances the benefit and cost of the integration of biological and social factors when modelling aetiology of disease.
Vols. 12-20 include: Cigar Maker's International Union of America. Annual financial report (title varies slightly), 1886-1894. (From 1886-1891 issued as a numbered section of the periodical.).