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Protein Post-Translational Modifications in the Nervous System: from Development to Disease and Ageing
Post-translational modifications (PTMs) increase the functional diversity of the proteome by reversibly or irreversibly modifying proteins during or after their synthesis. Thereby, they contribute to the structural and functional variety of proteins, conveying a complexity to the proteome that is significantly higher than the coding capacity of the genome. Moreover, providing another level of epigenetic regulation, PTMs of histone proteins in particular contribute to the modulation of gene accessibility and specific cell expression profiles. PTMs include enzymatically controlled modifications such as phosphorylation, glycosylation, acetylation, methylation, ubiquitination, or proteolysis as ...
Germanistik – Namenregister (1995-2004)
Das kumulierte Register enthält die Namen der Dichter und aller weiteren beteiligten bzw. erwähnten Personen sowie die Titel der anonymen Werke - insgesamt ca. 30.000 Eintragungen. Es ermöglicht einen umfassenden und bequemen Zugang zu den Daten des Referatenorgans »Germanistik« über einen Zeitraum von 10 Jahren. Die über die Jahre schwankenden Namenformen wurden (soweit machbar) vereinheitlicht, die Verweisungen vervollständigt. Um die Benutzung zu erleichtern, wurden die Titel kursiv gedruckt; bei den Referenzen wurden die einzelnen Jahrgänge der »Germanistik« durch Fettschrift hervorgehoben. Das 10jährige Namenregister spiegelt die Entwicklung der Forschung zu einzelnen Dichtern wider und zeigt die wissenschaftliche Aktivität und Interessen von Germanisten aus aller Welt.
Periodontitis and Systemic Diseases
The association between periodontitis and systemic diseases has become a hot topic in recent years. This comprehensive book reviews the clinical evidence and biological plausibility of the many systemic diseases that have been linked to periodontitis. Edited by Dr Josefine Hirschfeld and Prof Iain L.C. Chapple, experts in each field discuss the mechanisms at work, citing the available key literature and clearly summarising current knowledge and understanding of the associations between periodontitis and diabetes mellitus, cardiovascular diseases, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, respiratory diseases, pregnancy and fertility, malignancy, neurodegenerative diseases, stress and depression, and autoimmunity. Each chapter critically appraises the existing evidence, providing comprehensive, contemporary and well-considered insights into the clinical evidence and biological plausibility of each condition, as well as the limitations of existing studies and how these can be overcome in the future. Periodontitis and Systemic Diseases: Clinical Evidence and Biological Plausibility is an indispensable reference for both clinicians and researchers.
Prevention and Treatment of Periodontitis
This book is a compilation of articles by experts on the prevention and treatment of periodontal disease, many of which are full of data-based evidence from basic research perspectives or patient data.
Imaging in Neuroscience
As imaging technologies have revolutionized research in many areas of biology and medicine, neuroscientists have often pioneered the use of these new visualization techniques. This volume is an essential guide to discovering and implementing these techniques in the neuroscience lab.
Precision Medicine
Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. - Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods - Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation - Encompasses easy access to relevant approaches, interactions and original literature
Tackling Wasteful Spending on Health
Countries could potentially spend significantly less on health care with no impact on health system performance, or on health outcomes. This report reviews strategies put in place by countries to limit ineffective spending and waste.
