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Immunometabolic Mechanisms Underlying the Severity of COVID-19
  • Language: en
  • Pages: 308
The role of tumor-associated macrophages in tumor progression
  • Language: en
  • Pages: 129

The role of tumor-associated macrophages in tumor progression

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Approaching Complex Diseases
  • Language: en
  • Pages: 493

Approaching Complex Diseases

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor eff...

Angiogenesis and Tumor Metastasis
  • Language: en
  • Pages: 209

Angiogenesis and Tumor Metastasis

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Targeting Angiogenesis to Treat Autoimmune Diseases and Cancer
  • Language: en
  • Pages: 119
The regulation of angiogenesis by tissue cell-macrophage interactions
  • Language: en
  • Pages: 114

The regulation of angiogenesis by tissue cell-macrophage interactions

Angiogenesis is the physiological process where new blood vessels grow from existing ones, in order to replenish tissues suffering from inadequate blood supply. Perhaps the most studied angiogenic process occurs in solid tumors whose growing mass and expanding cells create a constant demand for additional supply of oxygen and nutrients for survival. However, other physiological and clinical conditions, such as wound healing, ischemic events, autoimmune and age-related diseases also involve angiogenesis. Angiogenesis is a well-structured process that begins when oxygen and nutrients are depleted, leading to the release of chemokines and growth factors that attract immune cells, particularly m...

Revisiting the Metastatic Cascade: Putting Myeloid Cells Into Context
  • Language: en
  • Pages: 245
Fighting an Elusive Enemy: Staphylococcus aureus and its Antibiotic Resistance, Immune-Evasion and Toxic Mechanisms
  • Language: en
  • Pages: 281

Fighting an Elusive Enemy: Staphylococcus aureus and its Antibiotic Resistance, Immune-Evasion and Toxic Mechanisms

Topic Editors Dr. Bagnoli and Dr. Phogat are employed by GlaxoSmithKline plc. The other Topic Editors Declare no conflict of interest in relation to the Research Topic theme

Protein Discovery Technologies
  • Language: en
  • Pages: 272

Protein Discovery Technologies

  • Type: Book
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  • Published: 2009-07-28
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  • Publisher: CRC Press

A True Insider's Guide to the Field - Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications o