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Neuroimaging Biomarkers and Cognition in Alzheimer’s disease Spectrum
Subjective cognitive decline (SCD) with self-reported concerns and mild cognitive impairment (MCI) are well-established to be at increased risk of developing Alzheimer’s disease (AD) dementia and a clinical continuum of dementia progression as a spectrum of AD. AD may develop from SCD to MCI (early MCI and late MCI) and eventually to AD. Nevertheless, until recently little was known about their pathophysiology associated with cognitive-behavioral syndrome. Although for researchers, scientists and clinicians, the pathophysiology of AD spectrum is an intriguing issue, delineating it in a clear way is far from easy. Taken together, in-depth understanding of neuroimaging-based pathology behind...
COVID and Emerging Infectious Diseases
Over the last two years with the strain of coronavirus having a devastating effect on the world’s healthcare system and triggering a global "lockdown", one question that has emerged; What, or which infectious disease is going to hit us next? Many infectious diseases prevalent in humans and animals are caused by pathogens that once emerged from other animal hosts. In addition to these established or re-emerging infections, new infectious diseases periodically emerge. In extreme cases they may lead to pandemics as we currently are seeing. The increased urbanization and globalization of the world order with faster connectivity and traveling has further in-creased the risk factors for emerging...
Mister Lee's Fantastic Football Dream
Singaporean teenager Lee Jun Yong dreams of becoming a professional footballer. Growing up in a family of humble means, in the shadow of Bedok Stadium, the sixteen-year-old is unsure what the future has in store for him. Then one day a chance encounter and some fancy footwork lead to a trial with local professional soccer team Geylang United and suddenly it seems as if Jun Yong’s dream is about to come true. Armed with his grandfather’s Tiger Balm and qi gong training, can Jun Yong make the under-18 national squad and represent his country against Australia? Teenage soccer fans worldwide will delight in Jun Yong’s football skills, despair at his dating skills, and empathise with his struggle to over come hardships and make his fantastic football dream become reality.
Gastrointestinal Variables and Drug Absorption
This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.
Missionaries, Mental Health, and Accountability
Hope and Help in Member Care. Culture shock. Marital strife. Depression. Addictions. Disillusionment. Organization and team tensions. Family trauma. Medical issues. This is not what you signed up for when you pursued missions. Field workers cross-linguistic, cultural, and ministry boundaries, but they still experience the same mental health challenges as everyone else—and often more. When the missionary unit includes a spouse and children, the complexities multiply as each person undergoes stressors. Needing psychological or psychiatric help too often leads to burnout or worse. It’s time to let go of the stigma and embrace mental health. Missionaries, Mental Health, and Accountability op...
