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Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
ACCMA Bulletin
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Face Book
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We the Animals
Three brothers tear their way through childhood - smashing tomatoes all over each other, building kites from rubbish, hiding when their parents do battle, tiptoeing around the house as their mother sleeps off her graveyard shift. Paps and Ma are from Brooklyn - he's Puerto Rican, she's white. Barely out of childhood themselves, their love is a serious, dangerous thing. Life in this family is fierce and absorbing, full of chaos and heartbreak and the euphoria of belonging completely to one another. From the intense familial unity felt by a child to the profound alienation he endures as he begins to forge his own way in the world, this beautiful novel reinvents the coming-of-age story in a way that is sly and incredibly powerful.
Advances in Web-Age Information Management
This book constitutes the refereed proceedings of the 4th International Conference on Web-Age Information Management, WAIM 2003, held in Chengdu, China in August 2003. The 30 revised full papers and 16 revised short papers presented together with 2 invited contributions were carefully reviewed and selected from 258 submissions. The papers are organized in topical sections on Web; XML; text management; data mining; bioinformatics; peer-to-peer systems; service networks; time series, similarity, and ontologies; information filtering; queries and optimization; multimedia and views; and systems demonstrations.
Air Force Register
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