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Recent Advances in Oral Immunity
The oral mucosa is a challenging environment from an immunological perspective, containing discrete niches with a unique architecture and function that requires precise adjustment of the immune system. Being the port of entry to the gastrointestinal and respiratory tracts, the oral cavity is also constantly challenged by antigens derived from air and food. Moreover, the oral cavity is the sole tissue of the body harboring a hard surface (i.e. the tooth) that is exposed to the hostile external environment, resulting in the formation of a complex biofilm that has local and systemic effects. To deal with such challenges, the oral immune system aims to prevent the invasion of pathogens/harmful antigens and to tolerate non-pathogenic counterparts in order to maintain homeostasis. In recent years, numerous studies have addressed these fundamental issues, revealing sophisticated mechanisms engaged by the immune system to maintain oral mucosal homeostasis and to combat various immunological insults. Some of these studies have identified novel immunological mechanisms, emphasizing the uniqueness of the oral immune system and the necessity to further investigate its functions.
Ja, legenda
Jakie istoty zostają legendami? Może ostatni człowiek na ziemi, kosmiczna kreatura albo szalony wynalazca. Małe stworzonka ze szczytów Himalajów, o których istnieniu nie mieliście pojęcia lub najbardziej sumienny kanar z koszmarów tych, którzy jeżdżą bez biletu. Może cizia z ajfonem. Artysta błądzący w mroku i szaleństwie pomiędzy obrazami, wędrowiec pośród snów, rycerz bez skazy, król marzyciel. Czy słyszeliście kiedyś myśli nanocząstek? Patrzyliście na koguta, który wzbija się pod sam sufit, pokonawszy grawitację? Czy chcecie poczuć świat, na chwilę wyłączając wzrok lub zarazić go swoimi emocjami tak, by przeżarły jego elementy niczym rdza? W Ja, legenda czeka na Was to i jeszcze więcej. Zbiór dwudziestu pięciu opowiadań to antologia zamykająca konkurs przeprowadzony pod okiem redakcji Fantazmatów na portalu fantastyka.pl.
Culture Builders
"Explains brilliantly the structures and processes of middle-class culture in historical perspective."--Robert Nye, Rutgers University " This] illuminating study of the Swedish middle class around the turn of the century . . . is one welcome sign that bourgeois, too, are once again recognized as parts of society worth studying . . . to be understood rather than to be savaged. Culture Builders is a welcome sign of yet another development: the ease with which historical studies may be integrated with neighboring disciplines."--Journal of Modern History "The authors take an impressively broad intellectual perspective. . . . The everyday routines of bourgeoisie, peasantry, and working class are ...
Walking on Madeira
A guidebook to 60 day walks on the Portuguese island of Madeira and neighbouring Porto Santo. Covering mountains, coast, laurisilva cloud forest and levadas (irrigation channels), routes range from easy strolls to more strenuous mountain hikes, some calling for a good head for heights. Walks range from 4 to 27km (2–17 miles) with options to combine routes to create longer days out. Sketch maps are included for each walk Detailed information on planning, facilities and public transport Highlights include an ascent of Pico de Areeiro, Madeira’s highest peak Easy access from Funchal
Nuclear Receptors
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working ...
Carpatho-Rusyn Studies
From modest chapels to majestic cathedrals, and historic synagogues to modern mosques and Buddhist temples: this photo-filled, pocket-size guidebook presents 1,079 houses of worship in Manhattan and lays to rest the common perception that skyscrapers, bridges, and parks are the only defining moments in the architectural history of New York City. With his exhaustive research of the city's religious buildings, David W. Dunlap has revealed (and at times unearthed) an urban history that reinforces New York as a truly vibrant center of community and cultural diversity. Published in conjunction with a New-York Historical Society exhibition, From Abyssinian to Zion is a sometimes quirky, always int...
Artificial Intelligence in Drug Design
This volume looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique, Artificial Intelligence in Drug Design is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists and drug designers.
Elenchus of Biblica
None
Reactive Drug Metabolites
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of her...
Women of Babylon
Representations of sexual difference (whether visual or textual) have become an area of much theoretical concern and investigation in recent feminist scholarship. Yet although a wide range of relevant evidence survives from the ancient Near East, it has been exceptional for those studying women in the ancient world to stray outside the traditional bounds of Greece and Rome. Women of Babylon is a much-needed historical/art historical study that investigates the concepts of femininity which prevailed in Assyro-Babylonian society. Zainab Bahrani's detailed analysis of how the culture of ancient Mesopotamia defined sexuality and gender roles both in, and through, representation is enhanced by a rich selection of visual material extending from 6500 BC - 1891 AD. Professor Bahrani also investigates the ways in which women of the ancient Near East have been perceived in classical scholarship up to the nineteenth century.
