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Evolving Concepts in Sepsis and Septic Shock
Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.
Sepsis
Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological ...
The Languages of COVID-19
This collection advocates languages-based, translational research to be part of the partnerships and collaborations required to make sense of, and respond to, COVID-19 as one of the major global challenges of our time. Bringing together scholars and practitioners from a wide range of disciplines, this volume is bound by a common thread stressing the importance of linguistic sensitivity, (inter)cultural knowledge and translational mediation in the frontline response to COVID-19. Featuring contributors from around the world and reflecting on the language used to frame COVID-19 in diverse cultural contexts of the Global North and Global South, the book proposes that paying attention to the tran...
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