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A Discursive Approach to Organizational and Strategy Consulting
People who strive to set things in motion within corporations and organizations, be it as managers or consultants, encounter stubborn resistance. Even though new strategies have been adopted, the desired changes do not materialize. A reorganization that was intended to finally produce clarity, creates only a new round of confusion. Wolfgang Schnelle, co-founder of the consulting firm Metaplan, learned from four decades of experience in the field that it pays to think of organizations and strategy within the context of opinions, interests, and power and trust relationships. His approach draws on organizational sociology and helps to shed light on the diverse realities of the players involved....
Growth Hormone And The Heart
Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.
Contributions of Physiology to the Understanding of Diabetes
Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heterogeneous diabetic syndrome are oriented towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events implicated in selective destruction of pancreatic ß-cell. In parallel, efforts are made for a better understanding of normal versus impaired biological actions, both of insulin and insulin-like growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.
Prader-Willi Syndrome
Over the past years, great advances have been made in the research of Prader-Willi Syndrome and its treatment options. The results raise hopes that the once depressing outlook for children with PWS and their parents will gradually give way to a much improved quality of life. Clinical research has shown that there is a hypothalamic growth hormone deficiency in PWS and that growth hormone treatment improves body composition, body proportions and physical performance of patients. Increased lean body mass enhances energy expenditure and - provided the energy input can be restrained - children no longer become obese. The disappearance of the obese phenotype in children with PWS who are treated wi...
The IGF System
It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide di...
The Messerschmitt 210/410 Story
In 1938, the Reichsluftfahrtsministerium (German Air Ministry, RLM), issued a requirement for a new twin-engine heavy fighter to replace the Me 110. This type of combat aeroplane was known as Zerstörer (Destroyer). The first prototype flew in September 1939. The Me 210 proved very difficult to fly, having numerous deficiencies. It was said to be deadlier to its crews than the enemy. Nevertheless, the Luftwaffe ordered the Me 210 into production. Operational trials began in late 1941, but it was eventually acknowledged that the aircraft had to be redesigned in order to be accepted into Luftwaffe service. The whole Me 210 debacle proved a huge scandal. A redesigned variant, the Me 410 began to reach Luftwaffe units in mid-1943. Even if the Me 210 and Me 410 were similar in appearance, the latter had to be redesigned to avoid the extremely poor reputation of the Me 210. The Me 410 proved a quite successful aeroplane, being used as a heavy fighter and for reconnaissance duties. Its closest Allied equivalent was the British DH 98 Mosquito. More than 1,500 Me 210/410s were built in Germany and Hungary, with only two Me 410s surviving today.
Vitamins and Hormones
Vitamins and Hormones
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
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