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A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting. These leading basic and fundamental authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews.
In 1862 London, the body of a famous surgeon is found, sitting upright, in an old operating theatre. His dead eyes stare at the table at the center of the room, where patients had screamed and cried as medical students looked on. The bookish Inspector Slaughter must discover the killer with the help of his American sergeant Mark Honeycutt and clues from Nightingale nurses, surgeon's dressers, devious apothecaries, and even stage actors. Victorian Southwark becomes the theatre for revealing secrets of the past in a world where anesthesia is new, working-class audiences enjoy Shakespeare, and women reformers solve society's problems.
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