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Novel cancer-related biomarkers
Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.
Kallikrein-related Peptidases
The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions.
Bradykinin, Kallidin and Kallikrein
Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely comple...
Bradykinin, Kallidin and Kallikrein
Bradykinin is frequently referred to as an elusive substance; the editor of a comprehensive volume dealing with kinins thus has a difficult task. The com plexity of the issues calls for a large number of contributors who approach the topics from the various angles that are dictated by the sometimes divergent views of the individuals. The editor saw no reason to prescribe the mode of presentation, which was left to the authors and accounts for the variety of approaches. Contributors from nine countries were asked to participate in the volume. The chapters were organized to present, first, the history of the discoveries and methods of approach to kinin research. Then follows a discussion of th...
Kallikreins: Advances in Research and Application: 2011 Edition
Kallikreins: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Kallikreins in a compact format. The editors have built Kallikreins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Kallikreins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Kallikreins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Characterization, regulation, and interactions within the protease web
This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function.
Bradykinin, Kallidin and Kallikrein
Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely comple...
Neutrophils and Altered Matrix - Induced Generation of Kallikrein Singlet Oxygen
Neutrophils are the cells that protect our lives against fungi, bacteria, or thrombi. In fungal or bacterial sepsis the flowing blood is exposed to unphysiologic matrices that fold factor 12 and prekallikrein into F12a and kallikrein. These two enzymes start the contact system of coagulation (altered matrix (AM) coagulation). The intrinsic ten-ase, factor 10a, thrombin, and micro-thrombi are formed. The neutrophils answer to increased blood concentrations of kallikrein (also a tissue enzyme) or micro-thrombi with intracellular NADPH-oxidase assembly and secretion of extracellular myeloperoxidase, together these enzymes generate reactive oxygen species (ROS) of the type of singlet oxygen, a s...
