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"When a thing ceases to be a subject of controversy, it ceases to be a subject of interest. " WILLIAM HAZLITT (1778-1830) This is the fourth volume in a series which we started in 1997. In 1976, Varco and Delaney edited a "surgical bestseller" entitled Controversy in Surgery. This was fol lowed by a second volume in 1985. The immense success of these books among both surgical trainees and experienced surgeons, and their wide international ap peal, supported the editors' notion that a view of controversy is integral to teach ing. However, despite major advances in surgical science and practice, no other similar publication has since been put together with the objective of addressing major con...
A Chicago PD analyst is thrust into the perilous underworld as she embarks on a desperate quest to find her missing brother in this intricately plotted thriller! Gang-related murders cast a dark shadow over the city as a new player emerges in the deadly fentanyl trade. Maude Kaminski, technical analyst for the Chicago PD, takes her place on the task force created to end the bloody territory wars. But Maude's world is upended when a child's backpack is discovered among the possessions of a dead homeless woman. The backpack belonged to Maude’s two-year-old brother, Michael, and is the first trace of him since he was taken — since Maude let someone take him — over twenty years ago. As Maude desperately searches for other signs of Michael she turns for help to her best friend, chef Sags Pfister, who harbors a dark past of her own. Long-buried secrets begin to surface, forcing Maude from behind her computer into undercover work and underneath the dark streets of Chicago, where she has to confront her deepest fears. How far would she go to protect her family? For fans of Janet Evanovich, readers will love this witty, tense, rollercoaster of a ride!
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A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book...