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Flavonoids and Anti-Aging
The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flav...
The Seven-day Rhythms of Life
Have you ever wondered why the entire earth operates on a seven-day cycle? Have you thought about how even some of the smallest animals seem to follow a weekly schedule? This is NOT a coincidence. Our amazing God, having created this world in seven days, has implanted in living things a very tiny yet powerful gland that transfers information within our bodies—or even between species—by biochemical, neurological, or photonic means. The pineal gland is the rhythm-maker of our bodies and is a testament to the Sabbath created by God in Eden. This seal of our Creator is non-changing and anchored in time. As you explore the various aspects of these biological rhythms in humans, animals, birds,...
Genomics-Driven Healthcare
This book evaluates trends arising in “-Omics” sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology. Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.
Nutraceuticals for Aging and Anti-Aging
Aging can be perceived differently during different times in one’s life. Aging as a process not only influences medical and economic dimensions at an individual level but also at societal and national levels. Aging is a natural process; however, its standard definition in a healthcare context is yet unclear. To delay the aging process and to maintain quality of life until the end of life are two goals of prime importance. Various healthcare approaches are being developed and experimented on to best manage aging as if it is a disease. Nutraceuticals are value-added dietary supplement products and have an immense potential in altering key structures and functions of aging. Nutraceuticals can...
Making Mind
Making Mind: Moral Sense and Consciousness in Philosophy, Science, and Literature posits the genesis of narrative as an adaptive function stemming from consciousness and moral sense. The book is unique with its idea of the individual character evolving narrative in relation to the group. Central to the argument is the claim that prehistorically, consciousness and moral sense intersected to form narrative. More than addressing the origin of story, the book examines and explains the evolution of narrative. The book is an interesting study of how our species-inherited moral sense can differ dramatically from one individual to another. While mores pertain to a group, narrative comes from and is processed by the individual and reaches its high point in the novel. We see how the moral sense works in characters as a monitor, and we feel it operating in us as readers in terms of approval, or not.
Art and Adaptability
Art and Adaptability argues for a co-evolution of theory of mind and material/art culture. The book covers relevant areas from great ape intelligence, hominin evolution, Stone Age tools, Paleolithic culture and art forms, to neurobiology. We use material and art objects, whether painting or sculpture, to modify our own and other people’s thoughts so as to affect behavior. We don’t just make judgments about mental states; we create objects about which we make judgments in which mental states are inherent. Moreover, we make judgments about these objects to facilitate how we explore the minds and feelings of others. The argument is that it’s not so much art because of theory of mind but art as theory of mind.
Cells in Space
Discussions and presentations addressed three aspects of cell research in space: the suitability of the cell as a subject in microgravity experiments, the requirements for generic flight hardware to support cell research, and the potential for collaboration between academia, industry, and government to develop these studies in space. Synopses are given for the presentations and follow-on discussions at the conference and papers are presented from which the presentations were based. An Executive Summary outlines the recommendations and conclusions generated at the conference.
Nutraceuticals and Health
Although health claims for nutraceuticals range from the fantastic to the sublime, most of these claims are based on cell culture studies and have not been validated in humans, making them inadequate for public health recommendations. Focusing on human population-based research (epidemiology studies), Nutraceuticals and Health: Review of Human Evid
Nitric Oxide Donors
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
