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Novel Insights into Adipose Cell Functions
Obesity is a disease of society and economic transition spreading at an epidemic pace throughout the world. According to the World Health Organization, obesity is defined as an increased or abnormal accumulation of body fat mass to the extent that individual’s health will be negatively affected. Overweight is thus being considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders.This volume provides the most up to date insights into the biology of a complex endocrine organ: the adipose tissue.
Physiology and Physiopathology of Adipose Tissue
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystoph...
From Obesity to Diabetes
Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.
Varieties of Russian Activism
Despite decades under Putin's rule, it is too simplistic to assert that authoritarianism in Russia has eliminated activism, especially in relation to everyday life. Instead, we must build an awareness of diverse efforts to mobilize citizens to better understand how activism is shaped by and, in turn, shapes the regime. Varieties of Russian Activism focuses on a broad range of collective actions addressing issues from labor organizing to housing renovation, religion, electoral politics, minority language rights, and urban planning. Contributors draw attention to significant forms of grassroots politics that have not received sufficient attention in scholarship or that deserve fresh examination. The volume shows that Russians find novel ways to redress everyday problems and demand new services. Together, these essays interrogate what kinds of practices can be defined as activism in a fast-changing, politically volatile society. An engaging collection, Varieties of Russian Activism unites leading scholars in the common aim of approaching the embeddedness of civic activism in the conditions of everyday life, connectedness, and rising society-state expectations.
Obesity
This book comprehensively accounts the current understanding of genetic mechanisms of obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and mutations, and current results from animal model research and genetic studies in human models. By presenting the impact of genetic factors in the development of obesity and key molec
Systemic and Non-Systemic Opposition in the Russian Federation
Over the period December 2011-July 2013 a tidal wave of mass protests swept through the Russian Capital and engulfed scores of cities and regions. Civil society, it appeared, had at last woken up. This fascinating book examines the rise and fall of the non-systemic opposition and the role of the systemic political opposition during this turbulent period. Leading experts in the field from Russia along with scholars from the UK and the US reflect on the conditions that have made large-scale protests possible, the types of people who have taken part and the goals of the opposition movement at both the national and regional levels. Contributors discuss what steps the regime has taken in response...
Adipose Tissue Biology
This book is designed to provide a comprehensive insight into current perspectives and challenges in adipose tissue biology. In Adipose Tissue Biology, scientists and clinicians discuss adipocyte precursors, differentiation and growth, brown and white adipose tissue, gender, inflammation, dietary and genetic determinants of fat mass, together with evolutionary and developmental aspects of adiposity.
Functional Foods, Ageing and Degenerative Disease
Degenerative diseases linked to ageing populations are a growing problem for the developed world. Edited by two authorities, this important collection reviews the role of functional foods in helping to prevent a number of such degenerative conditions, from osteoporosis and obesity to immune system disorders and cancer.The book begins with a number of introductory chapters which discuss the regulation of functional foods in the EU, the role of diet generally in preventing degenerative disease. Part one then examines bone and oral health with chapters on the use of diet to control osteoporosis, the use of functional ingredients to improve bone strength, and ways of maintaining dental health. P...
Yearbook of Pediatric Endocrinology 2012
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. Providing abstracts of articles that report the year's breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field, the Yearbook of Pediatric Endocrinology 2011 keeps busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists informed on n...
Intestinal Microbiota in Health and Disease
Now considered an organ with defensive and metabolic capabilities, the intestinal microbiota plays a major role in the local host immune system development and education. It contributes to the generation of a homeostatic balance characterized by the capacity to react against pathogens while remaining hyperresponsive/tolerant against commensals. Thi
