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How Not to Study a Disease
An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure. For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research. Herrup offers a...
Alzheimer's Disease
How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.
Rhythms of the Brain
Studies of mechanisms in the brain that allow complicated things to happen in a coordinated fashion have produced some of the most spectacular discoveries in neuroscience. This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the coevolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brain's fundamental organizer of neuronal information. The small-world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the ...
The Red Book
'Destined to be a classic . . . a sharply funny, clear-eyed examination, in the vein of Mary McCarthy's The Group, of the power and burden of privilege, the reality of being a modern woman and the lasting bonds of female friendship.' Vanity Fair Can a weekend change your life? Clover, Addison, Mia and Jane were college roommates until their graduation in 1989. Now, twenty years later, their lives are in free fall. Clover, once a securities broker with Lehman Brothers, living the Manhattan dream, is out of a job, newly married and fretting about her chances of having a baby. Addison's marriage to a novelist with writers' block is as stale as her artistic 'career'. Mia's acting ambitions never...
What's Wrong With My Mouse?
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutan...
Two Faces of Evil: Cancer and Neurodegeneration
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Empresses and Queens in the Courtly Public Sphere from the 17th to the 20th Century
This book analyzes the evolving interaction between court and media from an understudied perspective. Eight case studies focus on different European Empress consorts and Queen regnants from the seventeenth to the twentieth centuries, using a comparative, cross-media, and cross-period approach. The volume addresses a multitude of questions, ranging from how dynastic women achieved public prominence through their portraits; how their faces and bodies were moulded and rearticulated to fit varying expectations in the courtly public sphere; and the degree to which they, as female actors, engaged with or had agency within the processes of production and reception. In particular, two types of female rulership and their relationship to diverse media are contrasted, and lesser-known and under-researched dynastic women are spotlighted. Contributors: Christine Engelke, Anna Fabiankowitsch, Inga Lena Ångström Grandien, Titia Hensel, Andrea Mayr, Alison McQueen, Marion Romberg, and Alison Rowley.
The Politics of Dementia
Memory loss is not always viewed purely as a contingent neurobiological process present in an ageing population; rather, it is frequently related to larger societal issues and political debates. This edited volume examines how different media and genres – novels, auto/biographical writings, documentary as well as fictional films and graphic memoirs – represent dementia for the sake of critical explorations of memory, trauma and contested truths. In ten analytical chapters and one piece of graphic art, the contributors examine the ways in which what might seem to be the individual, ahistorical diseases of dementia are used in contemporary cultural texts to represent and respond to violent historical and political events – ranging from the Holocaust to postcolonial conditions – all of which can prove difficult to remember. Combining approaches from literary studies with insights from memory studies, trauma studies, anthropology, the critical medical humanities and media, film and comics studies, this volume explores the politics of dementia and incites new debates on cultures of remembrance, while remaining attentive to the lived reality of dementia.
