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The Neuronal Functions of EF-hand Ca(2+)-binding Proteins 2nd Edition
Ca2+ signaling in neurons is characterized by highly restricted and dynamic gradients called Ca2+ waves, spikes, transients and puffs depending upon their corresponding spatial and temporal features. Based on this strict segmentation the Ca2+ ion provides a versatile basis for complex signaling in neuronal subcompartments with a spatial resolution of micro- and nanodomains. The multitude of Ca2+-regulated processes requires specialized downstream processing machinery, translating the Ca2+ signal into alterations of cellular processes. The broad range of different Ca2+-triggered phenomena in neurons, ranging from neurotransmission to gene expression, is reflected by the existence of a multitu...
Neuronal Calcium Sensor Proteins
Calcium signalling is an astonishing example how a simple caption can trigger and regulate an enormous variety of cellular and physiological responses. Ca2+-signalling routes very often involve Ca2+-binding proteins that sense changes in intracellular [Ca2+] and trigger cellular responses by regulating specific targets. One fascinating group among these Ca2+-sensors are the neuronal calcium sensor (NCS) proteins, named for their localisation in neuronal tissue (although there are reports of their expression in non-neuronal tissues as well). While recent excellent reviews have covered key aspects of this protein group, the field expanded in recent years making it more and more difficult to represent every facet of this ongoing research endeavour. This book is intended to represent properties of NCS proteins.
Railway Empire 2 - The Official Guides
Railway Empire 2 puts you in the role of a railroad pioneer. Build railroads in North America and Europe, connect cities with fast lines, and outdo your competitors to revolutionize the transportation system. Sounds like a daunting task? Don't worry, with the help of these Official Guides, you can overcome any challenge. Step by step, you will go from apprentice to master of rail transport. In three books, you will find explanations of the game mechanics, important data, helpful tips, and hidden tricks for a successful game. In addition, you will find historical context on the locomotives and interesting background information on the campaign and scenarios to immerse you in the history of the railroad. Three books in one: The Official Compendium contains all the information you need to build a successful railroad company. The Official Mission Guide offers overviews of all the tasks you will face in the campaign and scenarios, as well as many useful tips. The Official Engine Catalogue is a complete listing of all the locomotives in the game, with all the relevant data and historical background.
A Serious Matter and True Joy
We tend to accept that German cities and states run their own cultural institutions (concert halls, theatres, museums). This book shows how this now “self-evident” fact became a reality in the course of the long nineteenth century.
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Photoreceptors and Calcium
This volume foxuses on the status of Ca2+ ions in regulation of phototransduction, light adaptation and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca2+-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events invovling Ca2+ in the retinal pigment epithelium, in synaptic transmission and secondary retinal neurons. A significant part of the book is dedicated to the role of Ca2+ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore association of gene defects with human retina disease and the generation of animal models of retinal degeneration.
Guanylate Cyclase
From somewhat enigmatic beginnings 40 years ago, guanylate cyclase research has emerged to occupy a position of prominence in the study of signal transduction. Guanylate cyclase has several intriguing features, including existence in two major forms, membrane and soluble, each independently regulated by distinct mechanisms. The membrane form gives rise to a fascinating signal transduction story important to both peptide hormones and sensory neurons. This volume covers the evolution of the field, peptide hormone receptor work, membrane guanylate cycles, related retinal diseases, and the biochemistry and physiology of the soluble form. The 16 chapters are written by leaders in the field.
Handbook of the Trees of New England
DigiCat Publishing presents to you this special edition of "Handbook of the Trees of New England" by Lorin Low Dame, Henry M. Brooks. DigiCat Publishing considers every written word to be a legacy of humankind. Every DigiCat book has been carefully reproduced for republishing in a new modern format. The books are available in print, as well as ebooks. DigiCat hopes you will treat this work with the acknowledgment and passion it deserves as a classic of world literature.
