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Analysis and Control of Cellular Ensembles. Exploiting dimensionality reduction in single-cell data and models
An ensemble system is a collection of nearly identical dynamical systems which admit a certain degree of heterogeneity, and which are subject to the restriction that they may only be manipulated or observed as a whole. This thesis presents analysis and control methods for cellular ensembles by considering reduced 1-dimensional dynamics of biological processes in high-dimensional single-cell data and models. To be more specific, we address the quest for real-time analysis of biological processes within single-cell data by introducing the measure-preserving map of pseudotime into real-time, in short MAPiT. MAPiT enables the reconstruction of temporal and spatial dynamics from single-cell snaps...
Emerging Applications of Control and Systems Theory
This book celebrates Professor Mathukumalli Vidyasagar’s outstanding achievements in systems, control, robotics, statistical learning, computational biology, and allied areas. The contributions in the book summarize the content of invited lectures given at the workshop “Emerging Applications of Control and Systems Theory” (EACST17) held at the University of Texas at Dallas in late September 2017 in honor of Professor Vidyasagar’s seventieth birthday. These contributions are the work of twenty-eight distinguished speakers from eight countries and are related to Professor Vidyasagar’s areas of research. This Festschrift volume will remain as a permanent scientific record of this event.
A mathematical modeling framework to simulate and analyze cell type transitions
The quantitative understanding of changes in cell types, referred to as cell type transitions, is fundamental to advance fields such as stem cell research, immunology, and cancer therapies. This thesis provides a mathematical modeling framework to simulate and analyze cell type transitions. The novel methodological approaches and models presented here address diverse levels which are essential in this context: Gene regulatory network models represent the cell type-determining gene expression dynamics. Here, a novel construction method for gene regulatory network models is introduced, which allows to transfer results from generic low-dimensional to realistic high-dimensional gene regulatory n...
Infectious Disease Management in Animal Shelters
Seit der Veröffentlichung der ersten Ausgabe von Infectious Disease Management in Animal Shelters 2009 haben Forschung und Praxis im Bereich der Tierheimmedizin beträchtliche Fortschritte gemacht. Diese aktualisierte zweite Auflage des bahnbrechenden Werks bildet den aktuellsten und umfassendsten Leitfaden in Bezug auf Vorbeugung von, Umgang mit und Behandlung von Infektionskrankheiten bei Katzen, Hunden und exotischen Kleinsäugern in Tierheimen. Über das gesamte Buch hinweg gelingt es den Autoren ? ausgewiesenen Experten auf dem Gebiet ? eine Brücke zwischen der medizinischen Behandlung (von Einzeltieren und Gruppen) und dem Umgang mit den Krankheiten zu schlagen. Das Werk enthält zah...
Microorganisms in Environmental Management
Microbes and their biosynthetic capabilities have been invaluable in finding solutions for several intractable problems mankind has encountered in maintaining the quality of the environment. They have, for example, been used to positive effect in human and animal health, genetic engineering, environmental protection, and municipal and industrial waste treatment. Microorganisms have enabled feasible and cost-effective responses which would have been impossible via straightforward chemical or physical engineering methods. Microbial technologies have of late been applied to a range of environmental problems, with considerable success. This survey of recent scientific progress in usefully applyi...
Mr Bligh's Bad Language
Captain Bligh and the mutiny on the Bounty have become proverbial in their capacity to evoke the extravagant and violent abuse of power. But William Bligh was one of the least violent disciplinarians in the British navy. It is this paradox which inspired Greg Dening to ask why the mutiny took place. His book explores the theatrical nature of what was enacted in the power-play on deck, on the beaches at Tahiti and in the murderous settlement at Pitcairn, on the altar stones and temples of sacrifice, and on the catheads from which men were hanged. Part of the key lies in the curious puzzle of Mr Bligh's bad language.
Computational Cell Biology
This textbook provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.
Dependence Modeling: Vine Copula Handbook
This book is a collaborative effort from three workshops held over the last three years, all involving principal contributors to the vine-copula methodology. Research and applications in vines have been growing rapidly and there is now a growing need to collate basic results, and standardize terminology and methods. Specifically, this handbook will (1) trace historical developments, standardizing notation and terminology, (2) summarize results on bivariate copulae, (3) summarize results for regular vines, and (4) give an overview of its applications. In addition, many of these results are new and not readily available in any existing journals. New research directions are also discussed.
Insect Nicotinic Acetylcholine Receptors
The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.
