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Mutation, Randomness, and Evolution
What does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact-based conclusion, but as the premise of a neo-Darwinian research program focused on selection. The successes of this research program created a blind spot - in mathematical models and verbal theories of causation - that has stymied efforts to re-think the role of variation. However, recent theoretical and empirical work shows that mutational biases can and do influence the course of evolution, in...
Venoms to Drugs
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered ...
Fevered Planet
A timely and urgent investigation from John Vidal, Environment Editor of the Guardian for nearly thirty years, into how the destruction of nature is releasing disease into our societies'Urgent, fascinating and essential' GEORGE MONBIOT'A searing, vital work' BETTANY HUGHESCovid-19, mpox, bird flu, SARS, HIV, AIDS, Ebola; we are living in the Age of Pandemics - one that we have created. As the climate crisis reaches a fever pitch and ecological destruction continues unabated, we are just beginning to reckon with the effects of environmental collapse on our global health.Fevered Planet exposes how the way we farm, what we eat, the places we travel to and the scientific experiments we conduct c...
Narratives in Times of Radical Transformation
This book explores how narratives have been and can be used to facilitate radical transformations towards a more sustainable future. Scholars from various disciplines have been increasingly utilizing social and cultural narratives to understand personal, social, and cultural transformations. These narratives offer guiding principles for achieving personal, social, and cultural transformations. Drawing on various fields such as psychoanalysis, psychology, sociology, technology, cultural studies, and related areas, this book presents different perspectives on narratives in situations of transformation, exploring both commonalities and differences. The interdisciplinary and transdisciplinary re...
The Origin and Early Evolutionary History of Snakes
Snakes comprise nearly 4,000 extant species found on all major continents except Antarctica. Morphologically and ecologically diverse, they include burrowing, arboreal, and marine forms, feeding on prey ranging from insects to large mammals. Snakes are strikingly different from their closest lizard relatives, and their origins and early diversification have long challenged and enthused evolutionary biologists. The origin and early evolution of snakes is a broad, interdisciplinary topic for which experts in palaeontology, ecology, physiology, embryology, phylogenetics, and molecular biology have made important contributions. The last 25 years has seen a surge of interest, resulting partly from new fossil material, but also from new techniques in molecular and systematic biology. This volume summarises and discusses the state of our knowledge, approaches, data, and ongoing debates. It provides reviews, syntheses, new data and perspectives on a wide range of topics relevant to students and researchers in evolutionary biology, neontology, and palaeontology.
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Venomous Reptiles and Their Toxins
Venom research and technology has advanced greatly, rapidly transforming our knowledge of reptile venoms. Research advances, like the development of molecular systematics, provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments have expanded our understanding of venom's evolution and its usefulness in therapeutic development. The results of this punctuated toxin molecular evolutionary expansion include protein neofunctionalization. While these changes may impact antivenom efficacy, this molecular diversity also facilitates their usefulness in the development of novel drug therapies. Venomous Reptiles And Their Toxins brings toge...
Machine Learning for Predictive Analysis
This book gathers papers addressing state-of-the-art research in the areas of machine learning and predictive analysis, presented virtually at the Fourth International Conference on Information and Communication Technology for Intelligent Systems (ICTIS 2020), India. It covers topics such as intelligent agent and multi-agent systems in various domains, machine learning, intelligent information retrieval and business intelligence, intelligent information system development using design science principles, intelligent web mining and knowledge discovery systems.
