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Wild Immunology—The Answers Are Out There
“Go into partnership with nature; she does more than half the work and asks none of the fee.” - Martin H. Fisher. Nature has undertaken an immense amount of work throughout evolution. The evolutionary process has provided a power of information that can address key questions such as - Which immune molecules and pathways are conserved across species? Which molecules and pathways are exploited by pathogens to cause disease? What methods can be broadly used or readily adapted for wild immunology? How does co-infection and exposure to a dynamic environment affect immunity? Section 1 addresses these questions through an evolutionary approach. Laboratory mice have been instrumental in dissecti...
The Cheating Cell
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of cont...
Marsupial Genetics and Genomics
Marsupials belong to the Class Mammalia, sharing some features with other mammals, yet they also possess many unique features. It is their differences from the more traditionally studied mammals, such as mice and humans, that is of greatest value to comparative studies. Sequencing of genomes from two distantly related marsupials, the short grey-tailed opossum from South America and the Australian tammar wallaby, has launched marsupials into the genomics era and accelerated the rate of progress in marsupial research. With the current worldwide concern for the plight of the endangered Tasmanian devil, marsupial genetics and genomics research is even more important than ever if this species is to be saved from extinction. This volume recounts some of the history of research in this field and highlights the most recent advances in the many different areas of marsupial genetics and genomics research.
Saving the Tasmanian Devil
The Tasmanian devil is threatened by Devil Facial Tumour Disease (DFTD), a transmissible form of cancer that has reduced the population by over 80%. Persecution, extreme climate events, vehicle collision and habitat destruction also put pressure on this endangered species. The recovery effort to save the Tasmanian devil commenced over 15 years ago as a collaborative initiative between the Tasmanian government, the Australian government, the Zoo and Aquarium Association Australasia, and many research institutions. Saving the Tasmanian Devil documents the journey taken by partner organisations in discovering what DFTD is, the effect it has on wild devil populations, and the outcomes achieved t...
Cancer Immunology
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume is focused on immunopathology of cancers. The interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the most recent research and new developments in the field. Over the past decade, understanding of the interactions between the immune system and cancerous cells has increased markedly, leading to the development of combinatorial immunotherapeutic strategies to combat cancer. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.
Macropods
This book covers the proceedings of a major 2006 symposium on macropods that brought together the many recent advances in the biology of this diverse group of marsupials, including research on some of the much neglected macropods such as the antilopine wallaroo, the swamp wallaby and tree-kangaroos. More than 80 authors have contributed 32 chapters, which are grouped into four themes: genetics, reproduction and development; morphology and physiology; ecology; and management. The book examines such topics as embryonic development, immune function, molar progression and mesial drift, locomotory energetics, non-shivering thermogenesis, mycophagy, habitat preferences, population dynamics, juvenile mortality in drought, harvesting, overabundant species, road-kills, fertility control, threatened species, cross-fostering, translocation and reintroduction. It also highlights the application of new techniques, from genomics to GIS. Macropods is an important reference for academics and students, researchers in molecular and ecological sciences, wildlife and park managers, and naturalists.
Saving the Tasmanian Devil
The Tasmanian devil is threatened by Devil Facial Tumour Disease (DFTD), a transmissible form of cancer that has reduced the population by over 80%. Hunting, extreme climate events, vehicle collision and habitat destruction also put pressure on this endangered species. The recovery effort to save the Tasmanian devil commenced over 15 years ago as a collaborative initiative between the Tasmanian government, the Australian government, the Zoo and Aquarium Association Australasia, and many research institutions. Saving the Tasmanian Devil documents the journey taken by partner organizations in discovering what DFTD is, the effect it has on wild devil populations, and the outcomes achieved throu...
Applied Environmental Genomics
DNA is the essence of life and the original ‘big data’. New technologies are allowing scientists to access and make sense of this information like never before, and they are using it to solve the world’s greatest environmental challenges. Applied Environmental Genomics synthesises the latest and most exciting uses of genomic technologies for environmental science and management. With an emphasis on diversity of applications and real-world demonstrations, leading researchers have contributed detailed chapters on innovative approaches to obtaining critical management-relevant information about the natural world. These chapters are complemented by perspective sections written by environmental managers who describe their experiences using genomics to support evidence-based decisions. Ideal for students, researchers and professionals working in natural resource management and policy, Applied Environmental Genomics is a comprehensive introduction to a fast-moving field that is transforming the practice of environmental management, with profound relevance to industry, government and the public.
Thylacine
Until the mid-20th century, the thylacine was the world’s largest carnivorous marsupial, and its disappearance has left many questions and contradictions. Alternately portrayed as a scourge and as a high value commodity, the thylacine’s ecology and behaviour were known only anecdotally. In recent years, its taxonomic position, ecology, behaviour and body size have all been re-examined scientifically, while advances in genetics have presented the potential for de-extinction. With 78 contributors, Thylacine: The History, Ecology and Loss of the Tasmanian Tiger presents an evidence-based profile of the thylacine, examining its ecology, evolution, encounters with humans, persecution, assumed extinction and its appearance in fiction. The final chapters explore the future for this iconic species – a symbol of extinction but also hope.
