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Metals and Neurodegeneration: Restoring the Balance
Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative ...
Biometals in Neurodegenerative Diseases
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approxi...
Astrocyte
A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.
O Paradoxo da Longevidade
O cirurgião cardiotorácico de renome mundial, Dr. Steven Gundry, sabe muito em que todos nós queremos viver para sempre — até atingirmos a meia-idade e testemunharmos o sofrimento dos nossos pais e até dos colegas. Como resolvemos o paradoxo de querer viver até uma idade avançada, enquanto continuamos a desfrutar dos benefícios da juventude? Este livro inovador contém a resposta. Ao trabalhar com milhares de pacientes, o Dr. Gundry descobriu que as “doenças do envelhecimento” que mais tememos não são simplesmente uma consequência da idade. Pelo contrário, são um subproduto da maneira como vivemos as nossas vidas. Em O Paradoxo da Longevidade, ele mapeia uma nova abordage...
오래도록 젊음을 유지하고 건강하게 죽는 법
뉴욕 타임즈, 아마존 베스트셀러! 《알츠하이머의 종말》의 저자 데일 브레드슨 박사 추천! 베스트셀러 《플랜트 패러독스》의 스티븐 건드리 박사가 알려주는 오래도록 젊음을 유지하고 건강하게 살 수 있는 놀라운 방법들! 세계적인 심장 전문의 스티븐 건드리 박사는 사람들이 중년에 접어들면서 부모님과 친구들이 건강을 잃고 고통받는 모습을 보며 아프지 않고 영원히 살기를 바라는 마음을 너무나 잘 알고 있다. 나이가 들어도 오래도록 건강하고 젊게 살기를 희망하는 이 역설적인 상황을 해결할 방법은 없을까? 수천 명...
Парадокс долголетия. Как оставаться молодым до глубокой старости
Знаете ли вы, что жители голубых зон – люди, живущие дольше всех на Земле, – питаются самой разнообразной едой? Вопрос не в том, что они едят, а в том, чего не едят. Новая книга доктора Гандри посвящена парадоксальным фактам, связанным с настоящим здоровым долголетием: животные жиры сокращают нашу жизнь, избыток железа в организме приводит к раннему увяданию, а быстрый метаболизм – способ жить ярко, но быстро. Сотни научно доказанных фактов и настоящая программа, включившись в которую вы сможете дожить до глубокой старости в полном здравии.
Geographic Citizen Science Design
Little did Isaac Newton, Charles Darwin and other ‘gentlemen scientists’ know, when they were making their scientific discoveries, that some centuries later they would inspire a new field of scientific practice and innovation, called citizen science. The current growth and availability of citizen science projects and relevant applications to support citizen involvement is massive; every citizen has an opportunity to become a scientist and contribute to a scientific discipline, without having any professional qualifications. With geographic interfaces being the common approach to support collection, analysis and dissemination of data contributed by participants, ‘geographic citizen scie...
WHO global air quality guidelines
The main objective of these updated global guidelines is to offer health-based air quality guideline levels, expressed as long-term or short-term concentrations for six key air pollutants: PM2.5, PM10, ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. In addition, the guidelines provide interim targets to guide reduction efforts of these pollutants, as well as good practice statements for the management of certain types of PM (i.e., black carbon/elemental carbon, ultrafine particles, particles originating from sand and duststorms). These guidelines are not legally binding standards; however, they provide WHO Member States with an evidence-informed tool, which they can use to inform legislation and policy. Ultimately, the goal of these guidelines is to help reduce levels of air pollutants in order to decrease the enormous health burden resulting from the exposure to air pollution worldwide.
Role of Inflammation in Environmental Neurotoxicity
Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics.
