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Combating Canine Cancers with Phytochemicals
Cancer is a serious and ever-growing health concern not only in humans but also in dogs. Considering the differences in average lifespans, people commonly experience the loss of their companion dogs, representing a traumatic event to pet owners. On the one hand, better nutrition and improved care with many recent advancements in veterinary medicine have allowed dogs to live longer. On the other hand, this has involved an increased prevalence of aging-related diseases, including different types of malignancies. In fact, cancer afflicts one in every three dogs, being the most common cause of canine death. Hence, dogs with cancer require treatment, but differently from the human oncology, there...
How Plant Flavonoids Affect the Outcome of Hormonal and Biological Cancer Therapies
Cancer is a steadily increasing public health concern and severe socio-economic burden all over the world. Based on the current statistics of the WHO, almost 10 million people lost their lives due to malignant disorders in 2020, implying that one in every six deaths is due to cancer. In parallel, the global population of cancer survivors is also growing, propelled by advances in early detection, diagnosis and treatment methods, but also by demographic aging. More and more cancer patients today decide to use dietary supplements and herbal products in order to enhance their overall health, delay the progression of disease, augment the outcome of conventional therapies, mitigate diagnosis-relat...
Dietary Flavonoids Interfere with Cancer Radiotherapy
In parallel with the continuous rise of cancer incidence, efficient treatment becomes an increasingly important public health concern. Radiotherapy has remained one of the most important anticancer approaches for clinical management of a variety of human tumors, as at least half of all oncological patients receive this therapy at some stages of their disease. With the hope to attain greater anticancer response, the interest in using natural plant-derived products as complementary treatments to conventional radiotherapy has substantially increased in the recent years. However, the interactions between phytochemicals and ionizing radiation are not always known and can be often unpredictable. T...
Plant Flavonoids Against Metastasis
Cancer poses a major threat to human health and is one of the leading causes of death worldwide. Today, we know that metastasis, a multistep process whereby tumor cells spread from the site of origin to distant organs, is responsible for most cancer mortality. In fact, more than 90% of cancer-related deaths are attributed to tumor metastasis. Unfortunately, there are no therapies currently available to specifically target metastasis of any human cancer types, and patients with distant metastases ultimately die from their disease. Current conventional treatment modalities are focused on the removal of tumors by surgical resection and/or the killing of malignant cells using cytotoxic chemother...
Flavonoids in the Fight Against Upper Gastrointestinal Tract Cancers
Flavonoids are plant secondary metabolites with a basic polyphenolic skeleton and anticancer properties have greatly attracted the interest of scientists already for several years. This structurally diverse group of phytochemicals can be found abundantly in various edible plant products, such as fruits and vegetables, tea and cocoa, nuts, spices, grains and medicinal herbs. In the past decades, numerous experimental studies have shown antiproliferative, proapoptotic, antiinflammatory, antiangiogenic, antiinvasive and antimetastatic activities of these compounds in different cancerous systems. Because of close contacts and interactions of ingested food components with the epithelial lining of...
Plant Flavonoids Affect Cancer Chemotherapeutic Efficacy
Despite intensive work on molecular carcinogenic mechanisms and novel drug development, cancer has still remained an incurable disease. With the hope to gain therapeutic advantage or miracle cure, more than 50% of cancer patients consume various kinds of herbal supplements when undergoing chemotherapeutic treatment with antineoplastic agents. However, numerous preclinical studies on combined treatment of various cancer cells with natural dietary flavonoids and chemotherapeutic drugs have revealed both desired (additive to synergistic) as well as undesired (antagonistic) interactions, meaning that coadministration of flavonoids and chemotherapeutic drugs can lead to both augmentation as well as abolishment of therapeutic efficacy. This book is the first one to systematically compile currently available information about the modulation of chemotherapeutic efficacy by flavonoids, hopefully being an assistant for cancer patients to make conscious choices in selecting proper plant products during chemotherapeutic treatment.
Fundamentals of Flavonoids and Their Health Benefits
"Flavonoids are a large group of naturally occurring polyphenols which are synthesized by plants as secondary metabolites. They are ubiquitously present throughout the plant kingdom and have several important roles in plant physiology, especially as pigments and defense agents. Humans have consumed flavonoids as major constituents of plant-based foods and herbal remedies since ancient times. Although the first evidence of a biological activity of flavonoids was reported almost hundred years ago, an explosive growth in the flavonoid research occurred in the 1990s, after several epidemiological studies showed an inverse association between the intake of flavonoids and the incidence of chronic ...
