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The unique role of strangeness in nuclear physics has recently attracted much attention, from both the theoretical and experimental viewpoints. This is due not only to the broad spectrum of possible hadron many-body systems with strangeness, but also to the fact that strangeness gives us an opportunity to study fundamental baryon-baryon interactions in a new perspective. Our knowledge of this subject has widened as the scope of hypernuclear experiments has expanded from strangeness exchange and the associated production reactions to hypernuclear weak decays, ? decays, cascade hypernuclei, double-? events, electroproduction of strangeness, etc. This trend will be accelerated by the full operation of new laboratories such as TJLab, COSY, DAèNE, JHF, MAMI, and others. Various aspects of those important and exciting topics are discussed in this book in order to get a perspective of this fast developing area of nuclear physics.
This volume details bioinformatics analysis, biochemical assays, recombinant protein expression and purification, methods to investigate protease activity in cell-based, organoids and in vivo systems, proteomics, transcriptomics, machine learning and novel approaches to target dysregulated protease activity in cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Immunotherapy: Methods and Protocols aims to provide the scientific community with a diverse and representative collection of state-of-the-art methods to investigate the protean functions of proteases in cancer biology.
This book continues the biannual series of conference proceedings, which has become a classical reference resource in traffic and granular research alike. It addresses new developments at the interface between physics, engineering and computational science. Complex systems, where many simple agents, be they vehicles or particles, give rise to surprising and fascinating phenomena. The contributions collected in these proceedings cover several research fields, all of which deal with transport. Topics include highway, pedestrian and internet traffic, granular matter, biological transport, transport networks, data acquisition, data analysis and technological applications. Different perspectives, i.e. modeling, simulations, experiments and phenomenological observations, are considered.
Thermal noise from optical coatings is a growing area of concern and overcoming limits to the sensitivity of high precision measurements by thermal noise is one of the greatest challenges faced by experimental physicists. In this timely book, internationally renowned scientists and engineers examine our current theoretical and experimental understanding. Beginning with the theory of thermal noise in mirrors and substrates, subsequent chapters discuss the technology of depositing coatings and state-of-the-art dielectric coating techniques used in precision measurement. Applications and remedies for noise reduction are also covered. Individual chapters are dedicated to specific fields where coating thermal noise is a particular concern, including the areas of quantum optics/optomechanics, gravitational wave detection, precision timing, high-precision laser stabilisation via optical cavities and cavity quantum electrodynamics. While providing full mathematical detail, the text avoids field-specific jargon, making it a valuable resource for readers with varied backgrounds in modern optics.
This book constitutes the refereed proceedings of the 6th International Conference on Cellular Automata for Research and Industry, ACRI 2004, held in Amsterdam, The Netherlands in October 2004. The 60 revised full papers and 30 poster papers presented were carefully reviewed and selected from 150 submissions. The papers are devoted to methods and theory; evolved cellular automata; traffic, networks, and communication; applications in science and engineering; biomedical applications, natural phenomena and ecology; and social and economical applications.