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Life in the Frozen State
While it is barely 50 years since the first reliable reports of the recovery of living cells frozen to cryogenic temperatures, there has been tremendous growth in the use of cryobiology in medicine, agriculture, horticulture, forestry, and the conservation of endangered or economically important species. As the first major text on cryobiolog
Protein Adaptations and Signal Transduction
This volume of Cell and Molecular Responses to Stress has two broad themes: an examination of selected protein adaptations that support stress tolerance and an analysis of signal transduction systems, those critical links between the perception of stress and the activation of the coordinated metabolic responses that ensure survival. Several chapters deal with adaptive responses to environmental cold temperature and highlight novel advances in mammalian hibernation, low temperature enzyme function, cold-shock and antifreeze proteins, and freezing survival. Other chapters stretch out to explore biochemical responses to diverse stresses including water stress, mechanical stress, nutrient availa...
Functional Metabolism
Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is...
Advances in Comparative and Environmental Physiology
When survival is challenged by the cold, animals react by employing both behavioral and physiological solutions. Depending on the magni tude of the cold stress and the nature of the adjustment, simple avoidance or sophisticated capacity or resistance compensations may be used. Thus, migration, shelter seeking, metabolic and insulative compen sation, torpor, and freezing avoidance and tolerance are successful tac tics used by diverse groups of animals. To understand and appreciate the benefits of these tactics, it is necessary to examine not only the well being of the whole animal but also their basic underlying mechanisms. In ad dition, it is also of fundamental importance to grasp how seaso...
Advances in Clinical Chemistry
Volume 47 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. Leading experts from academia and clinical laboratory science Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies
Sensing, Signaling and Cell Adaptation
In this volume of Cell and Molecular Responses to Stress articles provide up-to-date information on key areas of signal sensing (sensing of pain, heat, cold, light, infrared radiation), molecules involved in the intracellular transmission of these signals, metabolic responses to stress including changes in gene expression and production of specialized proteins that aid cell responses to factors including interrupted blood supply (ischemia), oxygen limitation (hypoxia/anoxia), freezing and dehydration, amino acid limitation, radiation and processing drugs. There are chapters which also provide insights into new technologies (such as cDNA arrays), analysis of metabolic control theory (a key method for analysing stress effects on cells), and examine how enzymes evolve in the face of stress.
Life in the Cold
This book contains the proceedings of the 11 'h international symposium dedicated to the understanding of animal "Life in the Cold", held at Jungholz (Austria), August 13-18, 2000. In 55 chapters contributed by researchers from 16 countries the current state of knowledge is reviewed, and the most recent developments and discussions in this field are highlighted. The first symposium on hibernation and life in the cold was held in 1959, and from then on they continued to occur every 3-5 years. The regular occurrence of these meetings became almost a tradition. A tradition which is entirely based on the enthusiasm of participants, and was nourished by scientific progress in this area during the past decades. The first symposium in 1959 was organised by Charles P. Lyman and Albert R. Dawe and was almost entirely dedicated to hibernation and torpor. This has been a backbone topic of the following symposia, although other aspects of animal energetics, thermal physiology and biochemistry were included in later meetings.
Environmental Stressors and Gene Responses
Cell and Molecular Responses to Stress is a new multi-volume book series from Elsevier Science that focuses on how organisms respond at a molecular level to environmental stresses imposed upon them. All organisms deal with variations in multiple environmental factors including temperature, oxygen, salinity, and water availability. Many show amazing tolerances to extreme stress with remarkable biochemical adaptations that allow life to persist under very difficult circumstances. This series explores the molecular mechanisms by which cells and organisms respond to stress, focusing on the variations in metabolic response that allow some cells and organisms to deal with extreme stress, others to...
Thermobiology
Notwithstanding widespread studies and even several biological journals devoted to temperature, it is difficult to perceive a field of thermobiology as such. Interest in the effects of temperature of biological systems is fragmented into specific thermal ranges and often connected with particular applications: subzero cryobiology and preservation of cells and tissues or survival of poikilotherms, para-zero cryobiology and preservation of whole organs and survival of whole animals, intermediate ranges and physiological adaption and regulation, high temperatures and use of heat for killing cancer cells, very high temperatures and limits of biological structure. Yet it has not always been so, a...
