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Neuroinflammation is associated with a wide spectrum of acute and chronic diseases of the central and peripheral nervous system. It causes secondary damage, which is a major determinant for progression and outcome. Activated complement is suspected to be a key player to neuroinflammation. Complement is an important evolutionary ancient system for host anti-microbial aid. It serves the innate immunity and interfaces with the adaptive immunity. Complement recognizes non-cognate or altered-self antigens and devours 'unwanted' cells or cell compartments. Activation of complement leads to opsonisation of a target, inflammation by the release of anaphylatoxins, and damage of the target by the assembled membrane attack complex. Because complement can harm self-tissue, activation is tightly controlled by regulators. However, complement activation might be excessive and uncontrolled at sites of damage contributing to neuroinflammation leading to neurodegeneration.
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Hardbound. International Congress Series 1155These Proceedings will allow the wide dissemination of the present situation in the research on athero-thrombosis. The volume contains review presentations and new advances on all fields related to cardiovascular diseases: lipoprotein metabolism, genetic, epidemiology, vascular biology, thrombosis, hypertension, diabetes, obesity, nutrition, pharmacology, clinical trials, therapy and risk factors
Atherosclerosis V is a Saratoga Conference, the proceedings of which have been published continuously in the Annals as Volumes 454 (1985), 598 (1990), 748 (1995) and 811 (1997). The fifth conference represents the state of the art in atherosclerosis research, from the level of clinical manifestations in diseased arteries, to underlying cellular and molecular mechanisms. Contributors from a spectrum of basic researchers and clinician scientists from around the world are included, along with excerpts of the actual discussion that took place at the meeting. The volume should be useful to all those interested in the important field of biomedical research on this public health problem from a basic, clinical, or translational perspective.
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Voorts een alphabetische lijst van Nederlandsche boeken in België uitgegeven.
With 1901/1910-1956/1960 Repertoium is bound: Brinkman's Titel-catalohus van de gedurende 1901/1910-1956/1960 (Title varies slightly).
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati
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