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In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.
First Published in 1965. This study deals with the history of political thought in Germany from 1789 to 1815. It is the story of a nation awaking from a long sleep, commencing to think for itself, to modernize its institutions, to formulate its ideas of the pattern of society and the duties of the State. Modern German literature begins with Klopstock and Lessing. German political thinking comes even later, for it is the child of the French Revolution.
This handbook provides an updated comprehensive description of gravitational wave astronomy. In the first part, it reviews gravitational wave experiments, from ground and space based laser interferometers to pulsar timing arrays and indirect detection from the cosmic microwave background. In the second part, it discusses a number of astrophysical and cosmological gravitational wave sources, including black holes, neutron stars, possible more exotic objects, and sources in the early Universe. The third part of the book reviews the methods to calculate gravitational waveforms. The fourth and last part of the book covers techniques employed in gravitational wave astronomy data analysis. This book represents both a valuable resource for graduate students and an important reference for researchers in gravitational wave astronomy.
Hailed as "absolutely the best reference book on its subject" by Newsweek, American Musical Theatre: A Chronicle covers more than 250 years of musical theatre in the United States, from a 1735 South Carolina production of Flora, or Hob in the Well to The Addams Family in 2010. Authors Gerald Bordman and Richard Norton write an engaging narrative blending history, critical analysis, and lively description to illustrate the transformation of American musical theatre through such incarnations as the ballad opera, revue, Golden Age musical, rock musical, Disney musical, and, with 2010's American Idiot, even the punk musical. The Chronicle is arranged chronologically and is fully indexed accordin...
This handbook covers anatomy and physiology before moving on to identification, investigation and management of specific endocrine disorders. As well as covering common and less common endocrine problems, there are also chapters on endocrine investigations and endocrine emergencies, designed for quick reference.
In this provocative and intricate analysis of the postbellum southern economy, Gavin Wright finds in the South’s peculiar labor market the answer to the perennial question of why the region remained backward for so long. After the Civil War, Wright explains, the South continued to be a low-wage regional market embedded in a high-wage national economy. He vividly details the origins, workings, and ultimate demise of that distinct system. The post-World War II southern economy, which created today’s Sunbelt, Wright shows, is not the result of the evolution of the old system, but the product of a revolution brought on by the New Deal and World War II that shattered the South’s stagnant structure and created a genuinely new, thriving order.
A co-publication of the World Bank, International Finance Corporation and Oxford University Press
"Orientalism imagines history as a conflict between 'East' and 'West' from the Greco-Persian Wars onward. An institutionalized, expert community represents this world of East and West with authority, as, for example, in media and policy discussions of the Islamic sources of terrorism. The essays in this volume, which include chapters by historian Bruce Cumings, feminist scholar Susan Jeffords, and cultural critic John Mowitt, explore three dimensions connecting Orientalism and war. The first concerns the representations of 'self' and 'other' that mark the place of Orientalism in war and which, for example, saturate media coverage of the War on Terror. The second follows the way in which host...
Written for parents and professionals who want to positively affect the development of infants, this book provides guidance to families for detecting early signs of preautism in their infant or toddler. The Cowden Preautism Observation Inventory (cpaoi) will help parents to establish a baseline of behaviors and skills, along with the use of recordings and videotaping, to justify further testing of their infant or toddler. If further assessment is needed, the parent has documented all behaviors and movements of his or her baby. A cluster of clinical and developmental signs and symptoms can be detected from medical information, complications during pregnancy, cognition/prelanguage, social-comm...