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NETosis 2: The Excitement Continues
NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nucle...
NETosis: At the Intersection of Cell Biology, Microbiology, and Immunology
NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflamma...
The Price of Honor
Some traditions are meant to be broken. Lailani has always known that being a woman means that she will never be a dragon rider, but when a messenger shows up demanding that all dragon riders must prepare for war, Lailani knows that her father’s crippling illness will get him killed. She must choose between two paths: let him go and die or put on his armor and go in his place. Disguising herself as a boy, she joins the dragon riders and finds herself facing danger at every turn. With her father’s dragon the only friend she can trust, Lailani must learn to be a warrior and fight to save her homeland … if she can keep her secret that long. Mulan meets Eragon in this epic tale! Fans of th...
The Role of Pentraxins: From Inflammation, Tissue Repair and Immunity to Biomarkers
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Kenmu
"The short-lived Kenmu regime (1333–1336) of Japanese Emperor Go-Daigo is often seen as an inevitably doomed, revanchist attempt to shore up the old aristocratic order. But far from resisting change, Andrew Edmund Goble here forcefully argues, the flamboyant Go-Daigo and his iconoclastic associates were among the competitors seeking to overcome the old order and renegotiate its structure and ethos. Their ultimate defeat did not automatically spell failure; rather, the revolutionary nature of their enterprise decisively moved Japan into its medieval age. By birth, education, and circumstances, Go-Daigo should have been a weak, fatalistic bit player. Instead this student of Chinese political theory was a bold actor with an unprecedented knowledge of the various regions of Japan, who forced situations to his own benefit and led a rebellion that overthrew the Kamakura bakufu. Kenmu: Go-Daigo’s Revolution tells his extraordinary personal story vividly, reexamines original sources to discover the real nature of the Kenmu polity, and sets both within the broader backdrop of social, economic, and intellectual change at a dynamic moment in Japanese history."
Yamakiri-warrior of the mist
This is the 2nd book in the Black Dove series. 14th century feudal Japan-After the Kenmu restoration Japan had experienced a short time of peace, this saw Go-Daigo rise to power and the dismemberment of the Kamakura Shogunate. However, dissatisfied with Go-Daigo's reluctance to meet the promises he has made in return for their support, the Samurai are now regrouping under the leadership of one of the old Minamoto Clan leaders-Takauji Ashikaga. In the midst of this uprising and after years of solitude, a highly skilled Ninja descends from his mountain retreat. His goal is to rid himself of the inner demons from his turbulent past that continue to haunt him. Borne out of witnessing the futility of war and its effect on people, especially himself, he is reluctant to continue on the warrior path. Along the way, he is confronted with people and places from his past, these draw out his inner demons and cause him to realise that his inner battles prove far more difficult to fight than any physical opponent.
The Origins of Japan’s Medieval World
This pioneering collection of 15 essays argues that Japan's medieval age began in the 14th century rather than the 12th, and marks the beginning of a fundamentally new debate about how Japan's lengthy classical period finally ended.
