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New Rapid-acting Antidepressants
This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.
New Research on Methamphetamine Abuse
Methamphetamine (METH) abuse has become a major public health problem world-wide, as demonstrated by increases in the number of emergency room visits, substance abuse treatment episodes, and arrests attributable to METH manufacture and abuse. However, there are currently no pharmacological treatments for the wide range of symptoms associated with METH abuse. One of the reasons for this problem is that our knowledge of the cellular and molecular mechanisms underlying the development of METH-induced psychosis and dependence is limited. This book presents a review of the recent findings on METH abuse in humans. First by describing the background and physiological effects of METH in humans. Next, by discussing the clinical findings on METH abusers derived using brain imaging techniques (single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance spectroscopy (MRS), and functional magnetic resonance imaging (fMRI)). Finally, by reviewing the potential therapeutic approaches for the treatment of METH abusers.
D-Frag! Vol. 7
When the Game Development Club decides to go to the mysterious "Famous Athlete Hashimoto's Adventure Island," Kenji knows it's not going to be a normal field trip. Once on the island, they meet up with game clubs from other schools for a tournament, but before it begins, four masket villains kidnap the master of ceremonies! Can Kenji and his clubmates rescue Famous Athlete Hashimoto and still squeeze in a leisurely visit to the beach?
The NMDA Receptors
This volume provides a history of and an update on the functional status of the NMDA receptors. The NMDA receptors are essential for neuronal development, synaptic plasticity, learning, and cell survival. It covers molecular, cellular, anatomical, biochemical, and behavioral aspects, to highlight their distinctive regulatory properties, their functional significance, and their therapeutic potential in a number of diseases. A group of international experts discuss the development of NMDA receptors, their basic functions, and how they are implicated in a wide range of diseases including depression, psychosis, and pain.
