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Cardiac Regeneration
This detailed book addresses major goals of regenerative medicine and the cardiovascular research community with techniques to replenish lost cardiomyocytes, avoid scar-associated pathology, and improve myocardial infarction (MI) outcomes. The collection begins with a section on cardiac injury models, including zebrafish, neonatal and adult mice, and pigs, and continues with sections covering culturing cardiomyocytes from different species as well as methods for labeling or manipulation of cardiac tissue for the purpose of answering questions in regeneration. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Regeneration: Methods and Protocols provides the latest models and methods used in the field of heart regeneration, designed for researchers interested in establishing these assays in their laboratories to reproduce or extend findings, and for familiarizing themselves with the field if it is new to them.
Heart Regeneration
This title presents the major advances of the last decade in the field of cardiac regeneration.
Cardiac Regeneration
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Tendon Regeneration
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respec...
Regeneration
"Many organisms are able to regenerate damaged tissues - from heart muscle after cardiac injury in mammals to entire limbs in organisms like the axolotl. This volume explores the biological basis of regeneration, examining the developmental pathways involved, the underlying molecular mechanisms and how this knowledge may ultimately be applied therapeutically"--
Endocardial Endothelium
Places the discovery of the key role of cardiac endothelial cells in the control and modulation of heart performance in historical perspective, emphasizing the contributions of numerous investigators since 1986. Summarizes the major morphological, embryological, and comparative physiological features of the cells, and details the two main hypotheses for understanding the underlying mechanisms of the interaction between cardiac endothelial cells and cardiomyocytes. Includes bandw photos. Annotation copyright by Book News, Inc., Portland, OR
Health by the People
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Development of the Cardiac Conduction System
The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.
Cardiac Growth and Regeneration
Mammalian cardiac muscle, unlike that in amphibians, reptiles and the mammalian atrium, cannot regenerate after injury, and the mechanism for the irreversible blockage of mitosis in these monocytes during early development is still not understood. This book attempts to study the mechanisms that control the cardiac muscle cell cycle so that treatments to initiate repair of the myocardium can be designed. An ideal model would allow study of cardiac muscle cells in the intact heart in the biochemical state they were in during foetal growth, when they were actively dividing. This volume gathers the most current information dealing with the regenerative potential of cardiac muscle in the vertebrate heart.
Fundamentals of Astrometry
Astrometry encompasses all that is necessary to provide the positions and motions of celestial bodies. This includes observational techniques, instrumentation, processing and analysis of observational data, reference systems and frames, and the resulting astronomical phenomena. Astrometry is fundamental to all other fields of astronomy, from the pointing of telescopes, to navigation and guidance systems, to distance and motion determinations for astrophysics. In the last few decades, new observational techniques have enabled improvements in accuracy by orders of magnitude. Starting from basic principles, this book provides the fundamentals for this new astrometry at milli- and micro-arcsecond accuracies. Topics include: basics of general relativity; co-ordinate systems; vectors, tensors, quaternions, and observational uncertainties; determination and use of the celestial and terrestrial reference systems and frames; applications of new observational techniques; present and future star catalogues and double star astrometry. This comprehensive reference will be invaluable for graduate students and research astronomers.
