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Mitochondria and Cancer
Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
Advances in Mitochondrial Medicine
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are act...
Orofacial Pain
HauptbeschreibungCompletely revised and updated, this new edition of the AAOP Guidelines educates readers on evidence-based assessment, diagnosis, and management of orofacial pain conditions based on the latest scientific knowledge. While the structure of the previous edition has been maintained, this book offers evidence-based concepts where available and reflects many significant changes in the field of orofacial pain. Important topics covered in detail include TMDs, neuropathic pain conditions, odontogenic pain, and mucogingival disorders.(Quintessenz Verlag / Quintessence Publishing).
A Grammar of Fongbe
This book is a reference grammar of Fongbe, a language which is part of the Gbe dialect cluster. It is spoken mainly in the former kingdom of Dahomey, which today comprises the southern areas of Benin and Togo. This book has three objectives: First, its main purpose is to provide a thorough description of the grammar of Fongbe. Second, this book provides language-specific syntactic tests which were developed in the course of this research. Finally, we provide the reader with the most exhaustive list possible of references on Fongbe, and on the Gbe languages in general. This book thus attempts to represent a "state of the art" of the language itself, and of the analyses proposed to account for its particular constructions. This book is of particular interest to Africanists, scholars interested in comparative linguistics or in the reconstruction of language families, and creolists who work on the languages spoken in the Caribbean area.
Biodiversity, Ecosystems, and Conservation in Northern Mexico
This book describes the biodiversity and biogeography of nothern Mexico, documents the biological importance of regional ecosystems and the impacts of human land use on the conservation status of plants and wildlife. It should become the standard source document for the conservation status of species and ecosystems in this region, which is of unusual biological interest because of its high biodiversity and highly varied landscape and biological zonation.
If Today Be Sweet
“Ultimately, [If Today Be Sweet] reflects on what makes an individual part of a community, and movingly depicts the heartaches, responsibilities, and rewards of family life—among one’s own blood relatives as well as one’s ‘family of choice.’ . . . [A] meditation on the complex process of building a new life.” — Charlotte Observer The recent death of her beloved husband, Rustom, has taken its toll on Tehmina Sethna. Now, while visiting her son, Sorab, in his suburban Ohio home, she is being asked to choose between continuing her old life in India and starting a new one in this unfamiliar country with her son, his American wife, and their child. Her destiny is uncertain, and soon the plight of two troubled young children next door will force the most difficult decision she has ever faced. Ultimately the journey is one that Tehmina must travel alone. Eloquently written, evocative, and unforgettable, If Today Be Sweet is a poignant look at issues of immigration, identity, family life, and hope.
House of the Fortunate Buddhas
A searingly funny and passionate fictional monologue of woman who refuses to accept the constraints of life in 1950s Brazil.
The Need to Touch
*Warning: Mature content* You can only win someone's heart once you've captured it. Nineteen year old Ryder Harrison grew up near a small town in Montana, working on the family's ranch and in love with his best friend, Landon Pennington. That was until his Grandfather decided he needed to go to college in California. Ryder promised his Mom before she died that he would finish his education. Staying true to his word, Ryder packs his clothes, and heads to California, confident that it would all be one big disaster. The only thing he hadn't planned on was meeting Bentley Carter. Twenty year old Bentley Carter has enough emotional issues to write his own 'How to Cope' manual. Surviving an abusiv...
The Turning Point
Synopsis coming soon.......
